GINA, aGAIN - p133

doi:10.1038/ng0207-133

Abstract - GINA, aGAIN | Full Text - GINA, aGAIN | PDF (55 KB) - GINA, aGAIN

Open-access database of candidate associations from a genome-wide SNP scan of the Framingham Heart Study - pp135 - 136

Alan Herbert, Marc E Lenburg, David Ulrich, Norman P Gerry, Karen Schlauch & Michael F Christman

doi:10.1038/ng0207-135

Full Text - Open-access database of candidate associations from a genome-wide SNP scan of the Framingham Heart Study | PDF (86 KB) - Open-access database of candidate associations from a genome-wide SNP scan of the Framingham Heart Study

On the cloning of animals from terminally differentiated cells - pp136 - 137

Konrad Hochedlinger & Rudolf Jaenisch

doi:10.1038/ng0207-136

Full Text - On the cloning of animals from terminally differentiated cells | PDF (92 KB) - On the cloning of animals from terminally differentiated cells

Reply to "On the cloning of animals from terminally differentiated cells" - pp137 - 138

Xiangzhong Yang, Tao Cheng, Li-Ying Sung, Shaorong Gao, Hongmei Shen, Hui Yu, Yifang Song, Sadie L Smith, David P Tuck, Kimiko Inoue & Sherman M Weissman

doi:10.1038/ng0207-137

Full Text - Reply to "On the cloning of animals from terminally differentiated cells" | PDF (298 KB) - Reply to "On the cloning of animals from terminally differentiated cells"

Cipher sleuth - p139

doi:10.1038/ng0207-139

Full Text - Cipher sleuth | PDF (258 KB) - Cipher sleuth

Latexin is a newly discovered regulator of hematopoietic stem cells - pp141 - 142

Gerald de Haan

doi:10.1038/ng0207-141

Full Text - Latexin is a newly discovered regulator of hematopoietic stem cells | PDF (476 KB) - Latexin is a newly discovered regulator of hematopoietic stem cells

See also: Article by Liang et al.

Fanconi anemia and breast cancer susceptibility - pp142 - 143

Ketan J Patel

doi:10.1038/ng0207-142

Full Text - Fanconi anemia and breast cancer susceptibility | PDF (205 KB) - Fanconi anemia and breast cancer susceptibility

See also: Brief Communication by Xia et al. | Brief Communication by Reid et al. | Brief Communication by Rahman et al.

Personalized medicine and quantitative trait transcripts - pp144 - 145

Douglas M Ruden

doi:10.1038/ng0207-144

Full Text - Personalized medicine and quantitative trait transcripts | PDF (118 KB) - Personalized medicine and quantitative trait transcripts

See also: Letter by Passador-Gurgel et al.

Micromanaging the response to Hedgehog - pp145 - 146

Philip Ingham

doi:10.1038/ng0207-145

Full Text - Micromanaging the response to Hedgehog | PDF (128 KB) - Micromanaging the response to Hedgehog

See also: Letter by Flynt et al.

A DNA methylation–based switch generates bistable gene expression - pp146 - 147

Matthew R Bennett & Jeff Hasty

doi:10.1038/ng0207-146

Full Text - A DNA methylation–based switch generates bistable gene expression | PDF (755 KB) - A DNA methylation–based switch generates bistable gene expression

See also: Letter by Lim & van Oudenaarden

Touching base - p149

doi:10.1038/ng0207-149

Full Text - Touching base | PDF (229 KB) - Touching base

Research highlights - p151

doi:10.1038/ng0207-151

Full Text - Research highlights | PDF (62 KB) - Research highlights

Human Genome Variation 2006: emerging views on structural variation and large-scale SNP analysis - pp153 - 155

Gonçalo Abecasis, Paul Kwong-Hang Tam, Carlos D Bustamante, Elaine A Ostrander, Stephen W Scherer, Stephen J Chanock, Pui-Yan Kwok & Anthony J Brookes

doi:10.1038/ng0207-153

Full Text - Human Genome Variation 2006: emerging views on structural variation and large-scale SNP analysis | PDF (88 KB) - Human Genome Variation 2006: emerging views on structural variation and large-scale SNP analysis

Epigenetic stem cell signature in cancer - pp157 - 158

Martin Widschwendter, Heidi Fiegl, Daniel Egle, Elisabeth Mueller-Holzner, Gilbert Spizzo, Christian Marth, Daniel J Weisenberger, Mihaela Campan, Joanne Young, Ian Jacobs & Peter W Laird

doi:10.1038/ng1941

Abstract - Epigenetic stem cell signature in cancer | Full Text - Epigenetic stem cell signature in cancer | PDF (213 KB) - Epigenetic stem cell signature in cancer | Supplementary information

Fanconi anemia is associated with a defect in the BRCA2 partner PALB2 - pp159 - 161

Bing Xia, Josephine C Dorsman, Najim Ameziane, Yne de Vries, Martin A Rooimans, Qing Sheng, Gerard Pals, Abdellatif Errami, Eliane Gluckman, Julian Llera, Weidong Wang, David M Livingston, Hans Joenje & Johan P de Winter

doi:10.1038/ng1942

Abstract - Fanconi anemia is associated with a defect in the BRCA2 partner PALB2 | Full Text - Fanconi anemia is associated with a defect in the BRCA2 partner PALB2 | PDF (184 KB) - Fanconi anemia is associated with a defect in the BRCA2 partner PALB2 | Supplementary information

See also: News and Views by Patel

Biallelic mutations in PALB2 cause Fanconi anemia subtype FA-N and predispose to childhood cancer - pp162 - 164

Sarah Reid, Detlev Schindler, Helmut Hanenberg, Karen Barker, Sandra Hanks, Reinhard Kalb, Kornelia Neveling, Patrick Kelly, Sheila Seal, Marcel Freund, Melanie Wurm, Sat Dev Batish, Francis P Lach, Sevgi Yetgin, Heidemarie Neitzel, Hany Ariffin, Marc Tischkowitz, Christopher G Mathew, Arleen D Auerbach & Nazneen Rahman

doi:10.1038/ng1947

Abstract - Biallelic mutations in : PALB2: cause Fanconi anemia subtype FA-N and predispose to childhood cancer | Full Text - Biallelic mutations in PALB2 cause Fanconi anemia subtype FA-N and predispose to childhood cancer | PDF (181 KB) - Biallelic mutations in PALB2 cause Fanconi anemia subtype FA-N and predispose to childhood cancer | Supplementary information

See also: News and Views by Patel

PALB2, which encodes a BRCA2-interacting protein, is a breast cancer susceptibility gene - pp165 - 167

Nazneen Rahman, Sheila Seal, Deborah Thompson, Patrick Kelly, Anthony Renwick, Anna Elliott, Sarah Reid, Katarina Spanova, Rita Barfoot, Tasnim Chagtai, Hiran Jayatilake, Lesley McGuffog, Sandra Hanks, D Gareth Evans, Diana Eccles, The Breast Cancer Susceptibility Collaboration (UK), Douglas F Easton & Michael R Stratton

doi:10.1038/ng1959

Abstract - PALB2: , which encodes a BRCA2-interacting protein, is a breast cancer susceptibility gene | Full Text - PALB2, which encodes a BRCA2-interacting protein, is a breast cancer susceptibility gene | PDF (145 KB) - PALB2, which encodes a BRCA2-interacting protein, is a breast cancer susceptibility gene | Supplementary information

See also: News and Views by Patel

The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease - pp168 - 177

Ekaterina Rogaeva, Yan Meng, Joseph H Lee, Yongjun Gu, Toshitaka Kawarai, Fanggeng Zou, Taiichi Katayama, Clinton T Baldwin, Rong Cheng, Hiroshi Hasegawa, Fusheng Chen, Nobuto Shibata, Kathryn L Lunetta, Raphaelle Pardossi-Piquard, Christopher Bohm, Yosuke Wakutani, L Adrienne Cupples, Karen T Cuenco, Robert C Green, Lorenzo Pinessi, Innocenzo Rainero, Sandro Sorbi, Amalia Bruni, Ranjan Duara, Robert P Friedland, Rivka Inzelberg, Wolfgang Hampe, Hideaki Bujo, You-Qiang Song, Olav M Andersen, Thomas E Willnow, Neill Graff-Radford, Ronald C Petersen, Dennis Dickson, Sandy D Der, Paul E Fraser, Gerold Schmitt-Ulms, Steven Younkin, Richard Mayeux, Lindsay A Farrer & Peter St George-Hyslop

doi:10.1038/ng1943

Abstract - The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease | Full Text - The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease | PDF (361 KB) - The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease | Supplementary information

The quantitative trait gene latexin influences the size of the hematopoietic stem cell population in mice - pp178 - 188

Ying Liang, Michael Jansen, Bruce Aronow, Hartmut Geiger & Gary Van Zant

doi:10.1038/ng1938

Abstract - The quantitative trait gene latexin influences the size of the hematopoietic stem cell population in mice | Full Text - The quantitative trait gene latexin influences the size of the hematopoietic stem cell population in mice | PDF (525 KB) - The quantitative trait gene latexin influences the size of the hematopoietic stem cell population in mice | Supplementary information

See also: News and Views by de Haan

PTEN-deficient intestinal stem cells initiate intestinal polyposis - pp189 - 198

Xi C He, Tong Yin, Justin C Grindley, Qiang Tian, Toshiro Sato, W Andy Tao, Raminarao Dirisina, Kimberly S Porter-Westpfahl, Mark Hembree, Teri Johnson, Leanne M Wiedemann, Terrence A Barrett, Leroy Hood, Hong Wu & Linheng Li

doi:10.1038/ng1928

Abstract - : PTEN: : -deficient intestinal stem cells initiate intestinal polyposis | Full Text - PTEN-deficient intestinal stem cells initiate intestinal polyposis | PDF (1,338 KB) - PTEN-deficient intestinal stem cells initiate intestinal polyposis | Supplementary information

Systematic pathway analysis using high-resolution fitness profiling of combinatorial gene deletions - pp199 - 206

Robert P St Onge, Ramamurthy Mani, Julia Oh, Michael Proctor, Eula Fung, Ronald W Davis, Corey Nislow, Frederick P Roth & Guri Giaever

doi:10.1038/ng1948

Abstract - Systematic pathway analysis using high-resolution fitness profiling of combinatorial gene deletions | Full Text - Systematic pathway analysis using high-resolution fitness profiling of combinatorial gene deletions | PDF (606 KB) - Systematic pathway analysis using high-resolution fitness profiling of combinatorial gene deletions | Supplementary information

A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1 - pp207 - 211

Jochen Hampe, Andre Franke, Philip Rosenstiel, Andreas Till, Markus Teuber, Klaus Huse, Mario Albrecht, Gabriele Mayr, Francisco M De La Vega, Jason Briggs, Simone Günther, Natalie J Prescott, Clive M Onnie, Robert Häsler, Bence Sipos, Ulrich R Fölsch, Thomas Lengauer, Matthias Platzer, Christopher G Mathew, Michael Krawczak & Stefan Schreiber

doi:10.1038/ng1954

First paragraph - A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in : ATG16L1 | Full Text - A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1 | PDF (370 KB) - A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1 | Supplementary information

A nonsynonymous SNP in PRKCH (protein kinase C ) increases the risk of cerebral infarction - pp212 - 217

Michiaki Kubo, Jun Hata, Toshiharu Ninomiya, Koichi Matsuda, Koji Yonemoto, Toshiaki Nakano, Tomonaga Matsushita, Keiko Yamazaki, Yozo Ohnishi, Susumu Saito, Takanari Kitazono, Setsuro Ibayashi, Katsuo Sueishi, Mitsuo Iida, Yusuke Nakamura & Yutaka Kiyohara

doi:10.1038/ng1945

First paragraph - A nonsynonymous SNP in : : PRKCH: : (protein kinase C [eta]) increases the risk of cerebral infarction | Full Text - A nonsynonymous SNP in PRKCH (protein kinase C ) increases the risk of cerebral infarction | PDF (343 KB) - A nonsynonymous SNP in PRKCH (protein kinase C ) increases the risk of cerebral infarction | Supplementary information

Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution - pp218 - 225

Agnar Helgason, Snæbjörn Pálsson, Gudmar Thorleifsson, Struan F A Grant, Valur Emilsson, Steinunn Gunnarsdottir, Adebowale Adeyemo, Yuanxiu Chen, Guanjie Chen, Inga Reynisdottir, Rafn Benediktsson, Anke Hinney, Torben Hansen, Gitte Andersen, Knut Borch-Johnsen, Torben Jorgensen, Helmut Schäfer, Mezbah Faruque, Ayo Doumatey, Jie Zhou, Robert L Wilensky, Muredach P Reilly, Daniel J Rader, Yu Bagger, Claus Christiansen, Gunnar Sigurdsson, Johannes Hebebrand, Oluf Pedersen, Unnur Thorsteinsdottir, Jeffrey R Gulcher, Augustine Kong, Charles Rotimi & Kári Stefánsson

doi:10.1038/ng1960

First paragraph - Refining the impact of : : TCF7L2: : gene variants on type 2 diabetes and adaptive evolution | Full Text - Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution | PDF (235 KB) - Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution | Supplementary information

Common genetic variants account for differences in gene expression among ethnic groups - pp226 - 231

Richard S Spielman, Laurel A Bastone, Joshua T Burdick, Michael Morley, Warren J Ewens & Vivian G Cheung

doi:10.1038/ng1955

First paragraph - Common genetic variants account for differences in gene expression among ethnic groups | Full Text - Common genetic variants account for differences in gene expression among ethnic groups | PDF (674 KB) - Common genetic variants account for differences in gene expression among ethnic groups | Supplementary information

Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo methylation in cancer - pp232 - 236

Yeshayahu Schlesinger, Ravid Straussman, Ilana Keshet, Shlomit Farkash, Merav Hecht, Joseph Zimmerman, Eran Eden, Zohar Yakhini, Etti Ben-Shushan, Benjamin E Reubinoff, Yehudit Bergman, Itamar Simon & Howard Cedar

doi:10.1038/ng1950

First paragraph - Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for : de novo: methylation in cancer | Full Text - Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo methylation in cancer | PDF (163 KB) - Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo methylation in cancer | Supplementary information

A stem cell–like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing - pp237 - 242

Joyce E Ohm, Kelly M McGarvey, Xiaobing Yu, Linzhao Cheng, Kornel E Schuebel, Leslie Cope, Helai P Mohammad, Wei Chen, Vincent C Daniel, Wayne Yu, David M Berman, Thomas Jenuwein, Kevin Pruitt, Saul J Sharkis, D Neil Watkins, James G Herman & Stephen B Baylin

doi:10.1038/ng1972

First paragraph - A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing | Full Text - A stem cell–like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing | PDF (1,064 KB) - A stem cell–like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing | Supplementary information

Telomere length regulates the epigenetic status of mammalian telomeres and subtelomeres - pp243 - 250

Roberta Benetti, Marta García-Cao & María A Blasco

doi:10.1038/ng1952

First paragraph - Telomere length regulates the epigenetic status of mammalian telomeres and subtelomeres | Full Text - Telomere length regulates the epigenetic status of mammalian telomeres and subtelomeres | PDF (438 KB) - Telomere length regulates the epigenetic status of mammalian telomeres and subtelomeres | Supplementary information

Chromosome-wide nucleosome replacement and H3.3 incorporation during mammalian meiotic sex chromosome inactivation - pp251 - 258

Godfried W van der Heijden, Alwin A H A Derijck, Eszter Pósfai, Maud Giele, Pawel Pelczar, Liliana Ramos, Derick G Wansink, Johan van der Vlag, Antoine H F M Peters & Peter de Boer

doi:10.1038/ng1949

First paragraph - Chromosome-wide nucleosome replacement and H3.3 incorporation during mammalian meiotic sex chromosome inactivation | Full Text - Chromosome-wide nucleosome replacement and H3.3 incorporation during mammalian meiotic sex chromosome inactivation | PDF (1,046 KB) - Chromosome-wide nucleosome replacement and H3.3 incorporation during mammalian meiotic sex chromosome inactivation | Supplementary information

Zebrafish miR-214 modulates Hedgehog signaling to specify muscle cell fate - pp259 - 263

Alex S Flynt, Nan Li, Elizabeth J Thatcher, Lilianna Solnica-Krezel & James G Patton

doi:10.1038/ng1953

First paragraph - Zebrafish : miR-214: modulates Hedgehog signaling to specify muscle cell fate | Full Text - Zebrafish miR-214 modulates Hedgehog signaling to specify muscle cell fate | PDF (589 KB) - Zebrafish miR-214 modulates Hedgehog signaling to specify muscle cell fate | Supplementary information

See also: News and Views by Ingham

Quantitative trait transcripts for nicotine resistance in Drosophila melanogaster - pp264 - 268

Gisele Passador-Gurgel, Wen-Ping Hsieh, Priscilla Hunt, Nigel Deighton & Greg Gibson

doi:10.1038/ng1944

First paragraph - Quantitative trait transcripts for nicotine resistance in : Drosophila melanogaster | Full Text - Quantitative trait transcripts for nicotine resistance in Drosophila melanogaster | PDF (166 KB) - Quantitative trait transcripts for nicotine resistance in Drosophila melanogaster | Supplementary information

See also: News and Views by Ruden

A multistep epigenetic switch enables the stable inheritance of DNA methylation states - pp269 - 275

Han N Lim & Alexander van Oudenaarden

doi:10.1038/ng1956

First paragraph - A multistep epigenetic switch enables the stable inheritance of DNA methylation states | Full Text - A multistep epigenetic switch enables the stable inheritance of DNA methylation states | PDF (399 KB) - A multistep epigenetic switch enables the stable inheritance of DNA methylation states | Supplementary information

See also: News and Views by Bennett & Hasty

Corrigendum: Gain-of-function SOS1 mutations cause a distinctive form of Noonan syndrome - p276

Marco Tartaglia, Len A Pennacchio, Chen Zhao, Kamlesh K Yadav, Valentina Fodale, Anna Sarkozy, Bhaswati Pandit, Kimihiko Oishi, Simone Martinelli, Wendy Schackwitz, Anna Ustaszewska, Joel Martin, James Bristow, Claudio Carta, Francesca Lepri, Cinzia Neri, Isabella Vasta, Kate Gibson, Cynthia J Curry, Juan Pedro López Siguero, Maria Cristina Digilio, Giuseppe Zampino, Bruno Dallapiccola, Dafna Bar-Sagi & Bruce D Gelb

doi:10.1038/ng0207-276a

Full Text - Corrigendum: Gain-of-function SOS1 mutations cause a distinctive form of Noonan syndrome | PDF (78 KB) - Corrigendum: Gain-of-function SOS1 mutations cause a distinctive form of Noonan syndrome

Corrigendum: A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressiva - p276

Eileen M Shore, Meiqi Xu, George J Feldman, David A Fenstermacher, The FOP International Research Consortium, Matthew A Brown & Frederick S Kaplan

doi:10.1038/ng0207-276b

Full Text - Corrigendum: A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressiva | PDF (78 KB) - Corrigendum: A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressiva

Corrigendum: Lamin B1 duplications cause autosomal dominant leukodystrophy - p276

Quasar S Padiath, Kazumasa Saigoh, Raphael Schiffmann, Hideaki Asahara, Takeshi Yamada, Anulf Koeppen, Kirk Hogan, Louis J Ptáek & Ying-Hui Fu

doi:10.1038/ng0207-276c

Full Text - Corrigendum: Lamin B1 duplications cause autosomal dominant leukodystrophy | PDF (78 KB) - Corrigendum: Lamin B1 duplications cause autosomal dominant leukodystrophy