Table of contents


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Editorial

Risky business p1415

doi:10.1038/ng1207-1415

Recent discoveries and improvements in technology have boosted the profile of 'personalized genomics'. But the demonstrated complexities of the genetics of common disease suggest caution—and an urgent need for more data, both in and out of the lab.


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Obituary

John Hilton Edwards 1928–2007 p1417

Victor A McKusick

doi:10.1038/ng1207-1417


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Book Review

Hairs and heirs p1419

Philip R. Reilly reviews The Genetic Strand: Exploring a Family History Through DNA by Edward Ball

doi:10.1038/ng1207-1419


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News and Views

Stalled polymerases and transcriptional regulation pp1421 - 1422

John W Tamkun

doi:10.1038/ng1207-1421

After initiating transcription, RNA polymerase II often stalls a short distance downstream of promoters. The recent discovery of stalled polymerases at a large number of eukaryotic promoters suggests that the regulation of stalling plays a more important role in gene expression and development than previously suspected.

This is an issue edsumm for 1421. Identification of the Palaeocene/Eocene thermal maximum in a marine sedimentary sequence shows that sea surface temperatures near the North Pole increased from roughly 18 degrees Celsius to over 23 degrees Celsius — such warm values imply the absence of ice and thus exclude the influence of ice-albedo feedbacks on this Arctic warming.

See also: Letter by Muse et al. | Letter by Zeitlinger et al.


Sudden and unexpected pp1422 - 1423

Rudi Balling

doi:10.1038/ng1207-1422

Infections have been implicated in sudden and unexpected deaths, but evidence of causality and insights into underlying mechanisms are lacking. Now, a new study in mice identifies a homeostatic mechanism that seems critical for stabilizing the host response after microbial infection.

This is an issue edsumm for 1422. Identification of the Palaeocene/Eocene thermal maximum in a marine sedimentary sequence shows that sea surface temperatures near the North Pole increased from roughly 18 degrees Celsius to over 23 degrees Celsius — such warm values imply the absence of ice and thus exclude the influence of ice-albedo feedbacks on this Arctic warming.

See also: Article by Croker et al.


High-maintenance proteins and hypertriglyceridemia pp1424 - 1425

Alan D Attie

doi:10.1038/ng1207-1424

Lipoprotein lipase, the enzyme that hydrolyzes fatty acids from triglycerides carried by circulating lipoproteins, resides on the surface of the capillary endothelium. Analysis of a hypertriglyceridemic mutant mouse has now identified a protein, LMF1, that is critical for the transport of active lipoprotein lipase through the secretory pathway.

See also: Letter by Péterfy et al.


Two sides of the same coin pp1425 - 1426

Andrea Gallavotti & Robert J Schmidt

doi:10.1038/ng1207-1425

Dramatically different mutant phenotypes usually reflect mutations in different genes, but this is not necessarily so, especially when microRNA regulation is involved. A beautiful example of this now comes from the discovery of the maize microRNA tasselseed4 and its target ids1/Tasselseed6, which uncovers a new facet in the control of inflorescence branching and sex determination in flowers.

See also: Letter by Chuck et al.


Touching base p1427

doi:10.1038/ng1207-1427


Research highlights p1429

doi:10.1038/ng1207-1429


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Brief Communications

Rheumatoid arthritis association at 6q23 pp1431 - 1433

Wendy Thomson, Anne Barton, Xiayi Ke, Steve Eyre, Anne Hinks, John Bowes, Rachelle Donn, Deborah Symmons, Samantha Hider, Ian N Bruce, Wellcome Trust Case Control Consortium, Anthony G Wilson, Ioanna Marinou, Ann Morgan, Paul Emery, YEAR Consortium, Angela Carter, Sophia Steer, Lynne Hocking, David M Reid, Paul Wordsworth, Pille Harrison, David Strachan & Jane Worthington

doi:10.1038/ng.2007.32

This is an issue edsumm for 32. Identification of the Palaeocene/Eocene thermal maximum in a marine sedimentary sequence shows that sea surface temperatures near the North Pole increased from roughly 18 degrees Celsius to over 23 degrees Celsius — such warm values imply the absence of ice and thus exclude the influence of ice-albedo feedbacks on this Arctic warming.


Mutations in TTBK2, encoding a kinase implicated in tau phosphorylation, segregate with spinocerebellar ataxia type 11 pp1434 - 1436

Henry Houlden, Janel Johnson, Christopher Gardner-Thorpe, Tammaryn Lashley, Dena Hernandez, Paul Worth, Andrew B Singleton, David A Hilton, Janice Holton, Tamas Revesz, Mary B Davis, Paolo Giunti & Nicholas W Wood

doi:10.1038/ng.2007.43

This is an issue edsumm for 43. Identification of the Palaeocene/Eocene thermal maximum in a marine sedimentary sequence shows that sea surface temperatures near the North Pole increased from roughly 18 degrees Celsius to over 23 degrees Celsius — such warm values imply the absence of ice and thus exclude the influence of ice-albedo feedbacks on this Arctic warming.


Cystatin C modulates cerebral beta-amyloidosis pp1437 - 1439

Stephan A Kaeser, Martin C Herzig, Janaky Coomaraswamy, Ellen Kilger, Maj-Linda Selenica, David T Winkler, Matthias Staufenbiel, Efrat Levy, Anders Grubb & Mathias Jucker

doi:10.1038/ng.2007.23


Cystatin C inhibits amyloid-beta deposition in Alzheimer's disease mouse models pp1440 - 1442

Weiqian Mi, Monika Pawlik, Magdalena Sastre, Sonia S Jung, David S Radvinsky, Andrew M Klein, John Sommer, Stephen D Schmidt, Ralph A Nixon, Paul M Mathews & Efrat Levy

doi:10.1038/ng.2007.29


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Articles

Genetic determinants of hair, eye and skin pigmentation in Europeans pp1443 - 1452

Patrick Sulem, Daniel F Gudbjartsson, Simon N Stacey, Agnar Helgason, Thorunn Rafnar, Kristinn P Magnusson, Andrei Manolescu, Ari Karason, Arnar Palsson, Gudmar Thorleifsson, Margret Jakobsdottir, Stacy Steinberg, Snæbjörn Pálsson, Fridbert Jonasson, Bardur Sigurgeirsson, Kristin Thorisdottir, Rafn Ragnarsson, Kristrun R Benediktsdottir, Katja K Aben, Lambertus A Kiemeney, Jon H Olafsson, Jeffrey Gulcher, Augie Kong, Unnur Thorsteinsdottir & Kari Stefansson

doi:10.1038/ng.2007.13

This is an issue edsumm for 13. Identification of the Palaeocene/Eocene thermal maximum in a marine sedimentary sequence shows that sea surface temperatures near the North Pole increased from roughly 18 degrees Celsius to over 23 degrees Celsius — such warm values imply the absence of ice and thus exclude the influence of ice-albedo feedbacks on this Arctic warming.


ATP-sensitive potassium channels mediate survival during infection in mammals and insects pp1453 - 1460

Ben Croker, Karine Crozat, Michael Berger, Yu Xia, Sosathya Sovath, Lana Schaffer, Ioannis Eleftherianos, Jean-Luc Imler & Bruce Beutler

doi:10.1038/ng.2007.25

See also: News and Views by Balling


Dynamic evolution of the innate immune system in Drosophila pp1461 - 1468

Timothy B Sackton, Brian P Lazzaro, Todd A Schlenke, Jay D Evans, Dan Hultmark & Andrew G Clark

doi:10.1038/ng.2007.60


Genomic analysis of Bartonella identifies type IV secretion systems as host adaptability factors pp1469 - 1476

Henri L Saenz, Philipp Engel, Michèle C Stoeckli, Christa Lanz, Günter Raddatz, Muriel Vayssier-Taussat, Richard Birtles, Stephan C Schuster & Christoph Dehio

doi:10.1038/ng.2007.38


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Letters

Two independent alleles at 6q23 associated with risk of rheumatoid arthritis pp1477 - 1482

Robert M Plenge, Chris Cotsapas, Leela Davies, Alkes L Price, Paul I W de Bakker, Julian Maller, Itsik Pe'er, Noel P Burtt, Brendan Blumenstiel, Matt DeFelice, Melissa Parkin, Rachel Barry, Wendy Winslow, Claire Healy, Robert R Graham, Benjamin M Neale, Elena Izmailova, Ronenn Roubenoff, Alexander N Parker, Roberta Glass, Elizabeth W Karlson, Nancy Maher, David A Hafler, David M Lee, Michael F Seldin, Elaine F Remmers, Annette T Lee, Leonid Padyukov, Lars Alfredsson, Jonathan Coblyn, Michael E Weinblatt, Stacey B Gabriel, Shaun Purcell, Lars Klareskog, Peter K Gregersen, Nancy A Shadick, Mark J Daly & David Altshuler

doi:10.1038/ng.2007.27

This is an issue edsumm for 27. Identification of the Palaeocene/Eocene thermal maximum in a marine sedimentary sequence.


Mutations in LMF1 cause combined lipase deficiency and severe hypertriglyceridemia pp1483 - 1487

Miklós Péterfy, Osnat Ben-Zeev, Hui Z Mao, Daphna Weissglas-Volkov, Bradley E Aouizerat, Clive R Pullinger, Philip H Frost, John P Kane, Mary J Malloy, Karen Reue, Päivi Pajukanta & Mark H Doolittle

doi:10.1038/ng.2007.24

This is an issue edsumm for 24. Identification of the Palaeocene/Eocene thermal maximum in a marine sedimentary sequence shows that sea surface temperatures near the North Pole increased from roughly 18 degrees Celsius to over 23 degrees Celsius — such warm values imply the absence of ice and thus exclude the influence of ice-albedo feedbacks on this Arctic warming.

See also: News and Views by Attie


Mutations in smooth muscle alpha-actin (ACTA2) lead to thoracic aortic aneurysms and dissections pp1488 - 1493

Dong-Chuan Guo, Hariyadarshi Pannu, Van Tran-Fadulu, Christina L Papke, Robert K Yu, Nili Avidan, Scott Bourgeois, Anthony L Estrera, Hazim J Safi, Elizabeth Sparks, David Amor, Lesley Ades, Vivienne McConnell, Colin E Willoughby, Dianne Abuelo, Marcia Willing, Richard A Lewis, Dong H Kim, Steve Scherer, Poyee P Tung, Chul Ahn, L Maximilian Buja, C S Raman, Sanjay S Shete & Dianna M Milewicz

doi:10.1038/ng.2007.6


A survey of genetic human cortical gene expression pp1494 - 1499

Amanda J Myers, J Raphael Gibbs, Jennifer A Webster, Kristen Rohrer, Alice Zhao, Lauren Marlowe, Mona Kaleem, Doris Leung, Leslie Bryden, Priti Nath, Victoria L Zismann, Keta Joshipura, Matthew J Huentelman, Diane Hu-Lince, Keith D Coon, David W Craig, John V Pearson, Peter Holmans, Christopher B Heward, Eric M Reiman, Dietrich Stephan & John Hardy

doi:10.1038/ng.2007.16


Loss of Trim24 (Tif1alpha) gene function confers oncogenic activity to retinoic acid receptor alpha pp1500 - 1506

Konstantin Khetchoumian, Marius Teletin, Johan Tisserand, Manuel Mark, Benjamin Herquel, Mihaela Ignat, Jessica Zucman-Rossi, Florence Cammas, Thierry Lerouge, Christelle Thibault, Daniel Metzger, Pierre Chambon & Régine Losson

doi:10.1038/ng.2007.15


RNA polymerase is poised for activation across the genome pp1507 - 1511

Ginger W Muse, Daniel A Gilchrist, Sergei Nechaev, Ruchir Shah, Joel S Parker, Sherry F Grissom, Julia Zeitlinger & Karen Adelman

doi:10.1038/ng.2007.21

See also: News and Views by Tamkun


RNA polymerase stalling at developmental control genes in the Drosophila melanogaster embryo pp1512 - 1516

Julia Zeitlinger, Alexander Stark, Manolis Kellis, Joung-Woo Hong, Sergei Nechaev, Karen Adelman, Michael Levine & Richard A Young

doi:10.1038/ng.2007.26

See also: News and Views by Tamkun


The maize tasselseed4 microRNA controls sex determination and meristem cell fate by targeting Tasselseed6/indeterminate spikelet1 pp1517 - 1521

George Chuck, Robert Meeley, Erin Irish, Hajime Sakai & Sarah Hake

doi:10.1038/ng.2007.20

See also: News and Views by Gallavotti & Schmidt


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Technical Report

Genome-wide in situ exon capture for selective resequencing pp1522 - 1527

Emily Hodges, Zhenyu Xuan, Vivekanand Balija, Melissa Kramer, Michael N Molla, Steven W Smith, Christina M Middle, Matthew J Rodesch, Thomas J Albert, Gregory J Hannon & W Richard McCombie

doi:10.1038/ng.2007.42


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Erratum

Erratum: Splinkerette PCR for more efficient characterization of gene trap events p1528

Carsten Horn, Jens Hansen, Frank Schnütgen, Claudia Seisenberger, Thomas Floss, Markus Irgang, Silke De-Zolt, Wolfgang Wurst, Harald von Melchner & Patricia Ruiz Noppinger

doi:10.1038/ng1207-1528


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