Risky business - p1415

doi:10.1038/ng1207-1415

Full Text - Risky business | PDF (126 KB) - Risky business

John Hilton Edwards 1928–2007 - p1417

Victor A McKusick

doi:10.1038/ng1207-1417

Full Text - John Hilton Edwards 1928–2007 | PDF (103 KB) - John Hilton Edwards 1928–2007

Hairs and heirs - p1419

Philip R. Reilly reviews The Genetic Strand: Exploring a Family History Through DNA by Edward Ball

doi:10.1038/ng1207-1419

Full Text - Hairs and heirs | PDF (117 KB) - Hairs and heirs

Stalled polymerases and transcriptional regulation - pp1421 - 1422

John W Tamkun

doi:10.1038/ng1207-1421

Full Text - Stalled polymerases and transcriptional regulation | PDF (272 KB) - Stalled polymerases and transcriptional regulation

See also: Letter by Muse et al. | Letter by Zeitlinger et al.

Sudden and unexpected - pp1422 - 1423

Rudi Balling

doi:10.1038/ng1207-1422

Full Text - Sudden and unexpected | PDF (355 KB) - Sudden and unexpected

See also: Article by Croker et al.

High-maintenance proteins and hypertriglyceridemia - pp1424 - 1425

Alan D Attie

doi:10.1038/ng1207-1424

Full Text - High-maintenance proteins and hypertriglyceridemia | PDF (351 KB) - High-maintenance proteins and hypertriglyceridemia

See also: Letter by Péterfy et al.

Two sides of the same coin - pp1425 - 1426

Andrea Gallavotti & Robert J Schmidt

doi:10.1038/ng1207-1425

Full Text - Two sides of the same coin | PDF (170 KB) - Two sides of the same coin

See also: Letter by Chuck et al.

Touching base - p1427

doi:10.1038/ng1207-1427

Full Text - Touching base | PDF (130 KB) - Touching base

Research highlights - p1429

doi:10.1038/ng1207-1429

Full Text - Research highlights | PDF (124 KB) - Research highlights

Rheumatoid arthritis association at 6q23 - pp1431 - 1433

Wendy Thomson, Anne Barton, Xiayi Ke, Steve Eyre, Anne Hinks, John Bowes, Rachelle Donn, Deborah Symmons, Samantha Hider, Ian N Bruce, Wellcome Trust Case Control Consortium, Anthony G Wilson, Ioanna Marinou, Ann Morgan, Paul Emery, YEAR Consortium, Angela Carter, Sophia Steer, Lynne Hocking, David M Reid, Paul Wordsworth, Pille Harrison, David Strachan & Jane Worthington

doi:10.1038/ng.2007.32

Abstract - Rheumatoid arthritis association at 6q23 | Full Text - Rheumatoid arthritis association at 6q23 | PDF (168 KB) - Rheumatoid arthritis association at 6q23 | Supplementary information

Mutations in TTBK2, encoding a kinase implicated in tau phosphorylation, segregate with spinocerebellar ataxia type 11 - pp1434 - 1436

Henry Houlden, Janel Johnson, Christopher Gardner-Thorpe, Tammaryn Lashley, Dena Hernandez, Paul Worth, Andrew B Singleton, David A Hilton, Janice Holton, Tamas Revesz, Mary B Davis, Paolo Giunti & Nicholas W Wood

doi:10.1038/ng.2007.43

Abstract - Mutations in : TTBK2: , encoding a kinase implicated in tau phosphorylation, segregate with spinocerebellar ataxia type 11 | Full Text - Mutations in TTBK2, encoding a kinase implicated in tau phosphorylation, segregate with spinocerebellar ataxia type 11 | PDF (447 KB) - Mutations in TTBK2, encoding a kinase implicated in tau phosphorylation, segregate with spinocerebellar ataxia type 11 | Supplementary information

Cystatin C modulates cerebral -amyloidosis - pp1437 - 1439

Stephan A Kaeser, Martin C Herzig, Janaky Coomaraswamy, Ellen Kilger, Maj-Linda Selenica, David T Winkler, Matthias Staufenbiel, Efrat Levy, Anders Grubb & Mathias Jucker

doi:10.1038/ng.2007.23

Abstract - Cystatin C modulates cerebral [beta]-amyloidosis | Full Text - Cystatin C modulates cerebral -amyloidosis | PDF (264 KB) - Cystatin C modulates cerebral -amyloidosis | Supplementary information

Cystatin C inhibits amyloid- deposition in Alzheimer's disease mouse models - pp1440 - 1442

Weiqian Mi, Monika Pawlik, Magdalena Sastre, Sonia S Jung, David S Radvinsky, Andrew M Klein, John Sommer, Stephen D Schmidt, Ralph A Nixon, Paul M Mathews & Efrat Levy

doi:10.1038/ng.2007.29

Abstract - Cystatin C inhibits amyloid-[beta] deposition in Alzheimer's disease mouse models | Full Text - Cystatin C inhibits amyloid- deposition in Alzheimer's disease mouse models | PDF (260 KB) - Cystatin C inhibits amyloid- deposition in Alzheimer's disease mouse models | Supplementary information

Genetic determinants of hair, eye and skin pigmentation in Europeans - pp1443 - 1452

Patrick Sulem, Daniel F Gudbjartsson, Simon N Stacey, Agnar Helgason, Thorunn Rafnar, Kristinn P Magnusson, Andrei Manolescu, Ari Karason, Arnar Palsson, Gudmar Thorleifsson, Margret Jakobsdottir, Stacy Steinberg, Snæbjörn Pálsson, Fridbert Jonasson, Bardur Sigurgeirsson, Kristin Thorisdottir, Rafn Ragnarsson, Kristrun R Benediktsdottir, Katja K Aben, Lambertus A Kiemeney, Jon H Olafsson, Jeffrey Gulcher, Augie Kong, Unnur Thorsteinsdottir & Kari Stefansson

doi:10.1038/ng.2007.13

Abstract - Genetic determinants of hair, eye and skin pigmentation in Europeans | Full Text - Genetic determinants of hair, eye and skin pigmentation in Europeans | PDF (394 KB) - Genetic determinants of hair, eye and skin pigmentation in Europeans | Supplementary information

ATP-sensitive potassium channels mediate survival during infection in mammals and insects - pp1453 - 1460

Ben Croker, Karine Crozat, Michael Berger, Yu Xia, Sosathya Sovath, Lana Schaffer, Ioannis Eleftherianos, Jean-Luc Imler & Bruce Beutler

doi:10.1038/ng.2007.25

Abstract - ATP-sensitive potassium channels mediate survival during infection in mammals and insects | Full Text - ATP-sensitive potassium channels mediate survival during infection in mammals and insects | PDF (541 KB) - ATP-sensitive potassium channels mediate survival during infection in mammals and insects | Supplementary information

See also: News and Views by Balling

Dynamic evolution of the innate immune system in Drosophila - pp1461 - 1468

Timothy B Sackton, Brian P Lazzaro, Todd A Schlenke, Jay D Evans, Dan Hultmark & Andrew G Clark

doi:10.1038/ng.2007.60

Abstract - Dynamic evolution of the innate immune system in : Drosophila | Full Text - Dynamic evolution of the innate immune system in Drosophila | PDF (752 KB) - Dynamic evolution of the innate immune system in Drosophila | Supplementary information

Genomic analysis of Bartonella identifies type IV secretion systems as host adaptability factors - pp1469 - 1476

Henri L Saenz, Philipp Engel, Michèle C Stoeckli, Christa Lanz, Günter Raddatz, Muriel Vayssier-Taussat, Richard Birtles, Stephan C Schuster & Christoph Dehio

doi:10.1038/ng.2007.38

Abstract - Genomic analysis of : Bartonella: identifies type IV secretion systems as host adaptability factors | Full Text - Genomic analysis of Bartonella identifies type IV secretion systems as host adaptability factors | PDF (567 KB) - Genomic analysis of Bartonella identifies type IV secretion systems as host adaptability factors | Supplementary information

Two independent alleles at 6q23 associated with risk of rheumatoid arthritis - pp1477 - 1482

Robert M Plenge, Chris Cotsapas, Leela Davies, Alkes L Price, Paul I W de Bakker, Julian Maller, Itsik Pe'er, Noel P Burtt, Brendan Blumenstiel, Matt DeFelice, Melissa Parkin, Rachel Barry, Wendy Winslow, Claire Healy, Robert R Graham, Benjamin M Neale, Elena Izmailova, Ronenn Roubenoff, Alexander N Parker, Roberta Glass, Elizabeth W Karlson, Nancy Maher, David A Hafler, David M Lee, Michael F Seldin, Elaine F Remmers, Annette T Lee, Leonid Padyukov, Lars Alfredsson, Jonathan Coblyn, Michael E Weinblatt, Stacey B Gabriel, Shaun Purcell, Lars Klareskog, Peter K Gregersen, Nancy A Shadick, Mark J Daly & David Altshuler

doi:10.1038/ng.2007.27

First paragraph - Two independent alleles at 6q23 associated with risk of rheumatoid arthritis | Full Text - Two independent alleles at 6q23 associated with risk of rheumatoid arthritis | PDF (362 KB) - Two independent alleles at 6q23 associated with risk of rheumatoid arthritis | Supplementary information

Mutations in LMF1 cause combined lipase deficiency and severe hypertriglyceridemia - pp1483 - 1487

Miklós Péterfy, Osnat Ben-Zeev, Hui Z Mao, Daphna Weissglas-Volkov, Bradley E Aouizerat, Clive R Pullinger, Philip H Frost, John P Kane, Mary J Malloy, Karen Reue, Päivi Pajukanta & Mark H Doolittle

doi:10.1038/ng.2007.24

First paragraph - Mutations in : LMF1: cause combined lipase deficiency and severe hypertriglyceridemia | Full Text - Mutations in LMF1 cause combined lipase deficiency and severe hypertriglyceridemia | PDF (351 KB) - Mutations in LMF1 cause combined lipase deficiency and severe hypertriglyceridemia | Supplementary information

See also: News and Views by Attie

Mutations in smooth muscle -actin (ACTA2) lead to thoracic aortic aneurysms and dissections - pp1488 - 1493

Dong-Chuan Guo, Hariyadarshi Pannu, Van Tran-Fadulu, Christina L Papke, Robert K Yu, Nili Avidan, Scott Bourgeois, Anthony L Estrera, Hazim J Safi, Elizabeth Sparks, David Amor, Lesley Ades, Vivienne McConnell, Colin E Willoughby, Dianne Abuelo, Marcia Willing, Richard A Lewis, Dong H Kim, Steve Scherer, Poyee P Tung, Chul Ahn, L Maximilian Buja, C S Raman, Sanjay S Shete & Dianna M Milewicz

doi:10.1038/ng.2007.6

First paragraph - Mutations in smooth muscle [alpha]-actin (: ACTA2: ) lead to thoracic aortic aneurysms and dissections | Full Text - Mutations in smooth muscle -actin (ACTA2) lead to thoracic aortic aneurysms and dissections | PDF (1,029 KB) - Mutations in smooth muscle -actin (ACTA2) lead to thoracic aortic aneurysms and dissections | Supplementary information

A survey of genetic human cortical gene expression - pp1494 - 1499

Amanda J Myers, J Raphael Gibbs, Jennifer A Webster, Kristen Rohrer, Alice Zhao, Lauren Marlowe, Mona Kaleem, Doris Leung, Leslie Bryden, Priti Nath, Victoria L Zismann, Keta Joshipura, Matthew J Huentelman, Diane Hu-Lince, Keith D Coon, David W Craig, John V Pearson, Peter Holmans, Christopher B Heward, Eric M Reiman, Dietrich Stephan & John Hardy

doi:10.1038/ng.2007.16

First paragraph - A survey of genetic human cortical gene expression | Full Text - A survey of genetic human cortical gene expression | PDF (376 KB) - A survey of genetic human cortical gene expression | Supplementary information

Loss of Trim24 (Tif1) gene function confers oncogenic activity to retinoic acid receptor alpha - pp1500 - 1506

Konstantin Khetchoumian, Marius Teletin, Johan Tisserand, Manuel Mark, Benjamin Herquel, Mihaela Ignat, Jessica Zucman-Rossi, Florence Cammas, Thierry Lerouge, Christelle Thibault, Daniel Metzger, Pierre Chambon & Régine Losson

doi:10.1038/ng.2007.15

First paragraph - Loss of : Trim24: (: Tif1[alpha]: ) gene function confers oncogenic activity to retinoic acid receptor alpha | Full Text - Loss of Trim24 (Tif1) gene function confers oncogenic activity to retinoic acid receptor alpha | PDF (634 KB) - Loss of Trim24 (Tif1) gene function confers oncogenic activity to retinoic acid receptor alpha | Supplementary information

RNA polymerase is poised for activation across the genome - pp1507 - 1511

Ginger W Muse, Daniel A Gilchrist, Sergei Nechaev, Ruchir Shah, Joel S Parker, Sherry F Grissom, Julia Zeitlinger & Karen Adelman

doi:10.1038/ng.2007.21

First paragraph - RNA polymerase is poised for activation across the genome | Full Text - RNA polymerase is poised for activation across the genome | PDF (425 KB) - RNA polymerase is poised for activation across the genome | Supplementary information

See also: News and Views by Tamkun

RNA polymerase stalling at developmental control genes in the Drosophila melanogaster embryo - pp1512 - 1516

Julia Zeitlinger, Alexander Stark, Manolis Kellis, Joung-Woo Hong, Sergei Nechaev, Karen Adelman, Michael Levine & Richard A Young

doi:10.1038/ng.2007.26

First paragraph - RNA polymerase stalling at developmental control genes in the : Drosophila melanogaster: embryo | Full Text - RNA polymerase stalling at developmental control genes in the Drosophila melanogaster embryo | PDF (437 KB) - RNA polymerase stalling at developmental control genes in the Drosophila melanogaster embryo | Supplementary information

See also: News and Views by Tamkun

The maize tasselseed4 microRNA controls sex determination and meristem cell fate by targeting Tasselseed6/indeterminate spikelet1 - pp1517 - 1521

George Chuck, Robert Meeley, Erin Irish, Hajime Sakai & Sarah Hake

doi:10.1038/ng.2007.20

First paragraph - The maize : tasselseed4: microRNA controls sex determination and meristem cell fate by targeting : Tasselseed6/indeterminate spikelet1 | Full Text - The maize tasselseed4 microRNA controls sex determination and meristem cell fate by targeting Tasselseed6/indeterminate spikelet1 | PDF (749 KB) - The maize tasselseed4 microRNA controls sex determination and meristem cell fate by targeting Tasselseed6/indeterminate spikelet1 | Supplementary information

See also: News and Views by Gallavotti & Schmidt

Genome-wide in situ exon capture for selective resequencing - pp1522 - 1527

Emily Hodges, Zhenyu Xuan, Vivekanand Balija, Melissa Kramer, Michael N Molla, Steven W Smith, Christina M Middle, Matthew J Rodesch, Thomas J Albert, Gregory J Hannon & W Richard McCombie

doi:10.1038/ng.2007.42

First paragraph - Genome-wide : in situ: exon capture for selective resequencing | Full Text - Genome-wide in situ exon capture for selective resequencing | PDF (517 KB) - Genome-wide in situ exon capture for selective resequencing | Supplementary information

Erratum: Splinkerette PCR for more efficient characterization of gene trap events - p1528

Carsten Horn, Jens Hansen, Frank Schnütgen, Claudia Seisenberger, Thomas Floss, Markus Irgang, Silke De-Zolt, Wolfgang Wurst, Harald von Melchner & Patricia Ruiz Noppinger

doi:10.1038/ng1207-1528

Full Text - Erratum: Splinkerette PCR for more efficient characterization of gene trap events | PDF (54 KB) - Erratum: Splinkerette PCR for more efficient characterization of gene trap events