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Nature Genetics 39, 1421 - 1422 (2007)
doi:10.1038/ng1207-1421
Stalled polymerases and transcriptional regulation
John W Tamkun1
- John W. Tamkun is in the Department of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, Santa Cruz, California 95064, USA. e-mail: tamkun@biology.ucsc.edu
Abstract
After initiating transcription, RNA polymerase II often stalls a short distance downstream of promoters. The recent discovery of stalled polymerases at a large number of eukaryotic promoters suggests that the regulation of stalling plays a more important role in gene expression and development than previously suspected.
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