Brief Communication abstract
Nature Genetics 39, 1431 - 1433 (2007)
Published online: 4 November 2007 | doi:10.1038/ng.2007.32
Rheumatoid arthritis association at 6q23
Wendy Thomson1, Anne Barton1, Xiayi Ke1, Steve Eyre1, Anne Hinks1, John Bowes1, Rachelle Donn1, Deborah Symmons1, Samantha Hider1, Ian N Bruce1, Wellcome Trust Case Control Consortium9, Anthony G Wilson2, Ioanna Marinou2, Ann Morgan3, Paul Emery3, YEAR Consortium9, Angela Carter4, Sophia Steer5, Lynne Hocking6, David M Reid6, Paul Wordsworth7, Pille Harrison7, David Strachan8 & Jane Worthington1
The Wellcome Trust Case Control Consortium (WTCCC) identified nine single SNPs putatively associated with rheumatoid arthritis at P = 1 
10-5 - 5 10-7 in a genome-wide association screen. One, rs6920220, was unequivocally replicated (trend P = 1.1 10-8) in a validation study, as described here. This SNP maps to 6q23, between the genes oligodendrocyte lineage transcription factor 3 (OLIG3) and tumor necrosis factor-
–induced protein 3 (TNFAIP3).
- Arthritis Research Campaign (arc)–Epidemiology Unit, Stopford Building, The University of Manchester, Manchester M13 9PT, UK.
- School of Medicine and Biomedical Sciences, The University of Sheffield, Sheffield S10 2JF, UK.
- Academic Unit of Musculoskeletal Disease, Chapel Allerton Hospital, Leeds LS7 4SA, UK.
- Academic Unit of Molecular Vascular Medicine, the Leeds Institute of Genetics, Health and Therapeutics (LIGHT) Laboratories, Clarendon Way, University of Leeds, Leeds LS2 9JT, UK.
- Clinical and Academic Rheumatology, Kings College Hospital National Health Service Foundation Trust, Denmark Hill, London SE5 9RS, UK.
- Bone Research Group, Department of Medicine and Therapeutics, University of Aberdeen, Aberdeen AB25 2ZD, UK.
- University of Oxford Institute of Musculoskeletal Sciences, Botnar Research Centre, Oxford OX3 7LD, UK.
- Division of Community Health Sciences, St George's, University of London, London SW17 0RE, UK.
- For full lists of members of these consortia, see Supplementary Note online.
Correspondence to: Jane Worthington1 e-mail: jane.worthington@manchester.ac.uk
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