Developing genetics for developing countries - p1287

doi:10.1038/ng.2007.500

Full Text - Developing genetics for developing countries | PDF (131 KB) - Developing genetics for developing countries

Erasure of MLH1 methylation in spermatozoa—implications for epigenetic inheritance - p1289

Megan P Hitchins & Robyn L Ward

doi:10.1038/ng1107-1289

Full Text - Erasure of MLH1 methylation in spermatozoa—implications for epigenetic inheritance | PDF (93 KB) - Erasure of MLH1 methylation in spermatozoa—implications for epigenetic inheritance

DNA and aging - p1291

Vilhelm A Bohr & Christina T Bohr reviews Aging of the Genome: The Dual Role of DNA in Life and Death by Jan Vijg

doi:10.1038/ng1107-1291

Full Text - DNA and aging | PDF (106 KB) - DNA and aging

Islamic ethical framework for research into and prevention of genetic diseases - pp1293 - 1298

Aida I Al Aqeel

doi:10.1038/ng.2007.14

Full Text - Islamic ethical framework for research into and prevention of genetic diseases | PDF (351 KB) - Islamic ethical framework for research into and prevention of genetic diseases

A gene harvest revealing the archeology and complexity of human disease - pp1299 - 1301

Enrico Petretto, Edison T Liu & Timothy J Aitman

doi:10.1038/ng1107-1299

Abstract - A gene harvest revealing the archeology and complexity of human disease | Full Text - A gene harvest revealing the archeology and complexity of human disease | PDF (210 KB) - A gene harvest revealing the archeology and complexity of human disease

Double Dutch for duplications - pp1303 - 1304

Ewan Birney

doi:10.1038/ng1107-1303

Full Text - Double Dutch for duplications | PDF (221 KB) - Double Dutch for duplications

See also: Article by Jiang et al.

How the dog got its spots - pp1304 - 1306

Gregory S Barsh

doi:10.1038/ng1107-1304

Full Text - How the dog got its spots | PDF (385 KB) - How the dog got its spots

See also: Brief Communication by Salmon Hillbertz et al. | Article by Karlsson et al.

Aging and cancer: killing two birds with one worm - pp1306 - 1307

Anne Brunet

doi:10.1038/ng1107-1306

Full Text - Aging and cancer: killing two birds with one worm | PDF (178 KB) - Aging and cancer: killing two birds with one worm

See also: Letter by Pinkston-Gosse & Kenyon

Building in resistance to endothelial cell death - pp1308 - 1309

Massimiliano Mazzone, Carmen Ruiz de Almodovar & Peter Carmeliet

doi:10.1038/ng1107-1308

Full Text - Building in resistance to endothelial cell death | PDF (529 KB) - Building in resistance to endothelial cell death

See also: Letter by Santoro et al.

Red sky in the morning, shepherd's warning - pp1309 - 1310

Vinod Kumar & Philip A Wigge

doi:10.1038/ng1107-1309

Full Text - Red sky in the morning, shepherd's warning | PDF (292 KB) - Red sky in the morning, shepherd's warning

See also: Letter by Franklin & Whitelam

Touching Base - p1311

doi:10.1038/ng1107-1311

Full Text - Touching Base | PDF (194 KB) - Touching Base

Research highlights - p1313

doi:10.1038/ng1107-1313

Full Text - Research highlights | PDF (82 KB) - Research highlights

A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk - pp1315 - 1317

Peter Broderick, Luis Carvajal-Carmona, Alan M Pittman, Emily Webb, Kimberley Howarth, Andrew Rowan, Steven Lubbe, Sarah Spain, Kate Sullivan, Sarah Fielding, Emma Jaeger, Jayaram Vijayakrishnan, Zoe Kemp, Maggie Gorman, Ian Chandler, Elli Papaemmanuil, Steven Penegar, Wendy Wood, Gabrielle Sellick, Mobshra Qureshi, Ana Teixeira, Enric Domingo, Ella Barclay, Lynn Martin, Oliver Sieber, members of the CORGI Consortium, David Kerr, Richard Gray, Julian Peto, Jean-Baptiste Cazier, Ian Tomlinson & Richard S Houlston

doi:10.1038/ng.2007.18

Abstract - A genome-wide association study shows that common alleles of : SMAD7: influence colorectal cancer risk | Full Text - A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk | PDF (239 KB) - A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk | Supplementary information

Duplication of FGF3, FGF4, FGF19 and ORAOV1 causes hair ridge and predisposition to dermoid sinus in Ridgeback dogs - pp1318 - 1320

Nicolette H C Salmon Hillbertz, Magnus Isaksson, Elinor K Karlsson, Eva Hellmén, Gerli Rosengren Pielberg, Peter Savolainen, Claire M Wade, Henrik von Euler, Ulla Gustafson, Åke Hedhammar, Mats Nilsson, Kerstin Lindblad-Toh, Leif Andersson & Göran Andersson

doi:10.1038/ng.2007.4

Abstract - Duplication of : FGF3: , : FGF4: , : FGF19: and : ORAOV1: causes hair ridge and predisposition to dermoid sinus in Ridgeback dogs | Full Text - Duplication of FGF3, FGF4, FGF19 and ORAOV1 causes hair ridge and predisposition to dermoid sinus in Ridgeback dogs | PDF (368 KB) - Duplication of FGF3, FGF4, FGF19 and ORAOV1 causes hair ridge and predisposition to dermoid sinus in Ridgeback dogs | Supplementary information

See also: News and Views by Barsh

Efficient mapping of mendelian traits in dogs through genome-wide association - pp1321 - 1328

Elinor K Karlsson, Izabella Baranowska, Claire M Wade, Nicolette H C Salmon Hillbertz, Michael C Zody, Nathan Anderson, Tara M Biagi, Nick Patterson, Gerli Rosengren Pielberg, Edward J Kulbokas, III, Kenine E Comstock, Evan T Keller, Jill P Mesirov, Henrik von Euler, Olle Kämpe, Åke Hedhammar, Eric S Lander, Göran Andersson, Leif Andersson & Kerstin Lindblad-Toh

doi:10.1038/ng.2007.10

Abstract - Efficient mapping of mendelian traits in dogs through genome-wide association | Full Text - Efficient mapping of mendelian traits in dogs through genome-wide association | PDF (1,035 KB) - Efficient mapping of mendelian traits in dogs through genome-wide association | Supplementary information

See also: News and Views by Barsh

Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants - pp1329 - 1337

Wellcome Trust Case Control Consortium & The Australo-Anglo-American Spondylitis Consortium (TASC)

doi:10.1038/ng.2007.17

Abstract - Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants | Full Text - Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants | PDF (364 KB) - Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants | Supplementary information

Network modeling links breast cancer susceptibility and centrosome dysfunction - pp1338 - 1349

Miguel Angel Pujana, Jing-Dong J Han, Lea M Starita, Kristen N Stevens, Muneesh Tewari, Jin Sook Ahn, Gad Rennert, Víctor Moreno, Tomas Kirchhoff, Bert Gold, Volker Assmann, Wael M ElShamy, Jean-François Rual, Douglas Levine, Laura S Rozek, Rebecca S Gelman, Kristin C Gunsalus, Roger A Greenberg, Bijan Sobhian, Nicolas Bertin, Kavitha Venkatesan, Nono Ayivi-Guedehoussou, Xavier Solé, Pilar Hernández, Conxi Lázaro, Katherine L Nathanson, Barbara L Weber, Michael E Cusick, David E Hill, Kenneth Offit, David M Livingston, Stephen B Gruber, Jeffrey D Parvin & Marc Vidal

doi:10.1038/ng.2007.2

Abstract - Network modeling links breast cancer susceptibility and centrosome dysfunction | Full Text - Network modeling links breast cancer susceptibility and centrosome dysfunction | PDF (2,218 KB) - Network modeling links breast cancer susceptibility and centrosome dysfunction | Supplementary information

Disruption of the basal body compromises proteasomal function and perturbs intracellular Wnt response - pp1350 - 1360

Jantje M Gerdes, Yangfan Liu, Norann A Zaghloul, Carmen C Leitch, Shaneka S Lawson, Masaki Kato, Philip A Beachy, Philip L Beales, George N DeMartino, Shannon Fisher, Jose L Badano & Nicholas Katsanis

doi:10.1038/ng.2007.12

Abstract - Disruption of the basal body compromises proteasomal function and perturbs intracellular Wnt response | Full Text - Disruption of the basal body compromises proteasomal function and perturbs intracellular Wnt response | PDF (754 KB) - Disruption of the basal body compromises proteasomal function and perturbs intracellular Wnt response | Supplementary information

Ancestral reconstruction of segmental duplications reveals punctuated cores of human genome evolution - pp1361 - 1368

Zhaoshi Jiang, Haixu Tang, Mario Ventura, Maria Francesca Cardone, Tomas Marques-Bonet, Xinwei She, Pavel A Pevzner & Evan E Eichler

doi:10.1038/ng.2007.9

Abstract - Ancestral reconstruction of segmental duplications reveals punctuated cores of human genome evolution | Full Text - Ancestral reconstruction of segmental duplications reveals punctuated cores of human genome evolution | PDF (974 KB) - Ancestral reconstruction of segmental duplications reveals punctuated cores of human genome evolution | Supplementary information

See also: News and Views by Birney

Genetic basis of proteome variation in yeast - pp1369 - 1375

Eric J Foss, Dragan Radulovic, Scott A Shaffer, Douglas M Ruderfer, Antonio Bedalov, David R Goodlett & Leonid Kruglyak

doi:10.1038/ng.2007.22

Abstract - Genetic basis of proteome variation in yeast | Full Text - Genetic basis of proteome variation in yeast | PDF (504 KB) - Genetic basis of proteome variation in yeast | Supplementary information

EphB–ephrin-B interactions suppress colorectal cancer progression by compartmentalizing tumor cells - pp1376 - 1383

Carme Cortina, Sergio Palomo-Ponce, Mar Iglesias, Juan Luis Fernández-Masip, Ana Vivancos, Gavin Whissell, Mireia Humà, Nerea Peiró, Lourdes Gallego, Suzanne Jonkheer, Alice Davy, Josep Lloreta, Elena Sancho & Eduard Batlle

doi:10.1038/ng.2007.11

First paragraph - EphB-ephrin-B interactions suppress colorectal cancer progression by compartmentalizing tumor cells | Full Text - EphB–ephrin-B interactions suppress colorectal cancer progression by compartmentalizing tumor cells | PDF (1,401 KB) - EphB–ephrin-B interactions suppress colorectal cancer progression by compartmentalizing tumor cells | Supplementary information

Recurrent DNA copy number variation in the laboratory mouse - pp1384 - 1389

Chris M Egan, Srinath Sridhar, Michael Wigler & Ira M Hall

doi:10.1038/ng.2007.19

First paragraph - Recurrent DNA copy number variation in the laboratory mouse | Full Text - Recurrent DNA copy number variation in the laboratory mouse | PDF (721 KB) - Recurrent DNA copy number variation in the laboratory mouse | Supplementary information

Evidence that homologous X-chromosome pairing requires transcription and Ctcf protein - pp1390 - 1396

Na Xu, Mary E Donohoe, Susana S Silva & Jeannie T Lee

doi:10.1038/ng.2007.5

First paragraph - Evidence that homologous X-chromosome pairing requires transcription and Ctcf protein | Full Text - Evidence that homologous X-chromosome pairing requires transcription and Ctcf protein | PDF (720 KB) - Evidence that homologous X-chromosome pairing requires transcription and Ctcf protein | Supplementary information

Birc2 (cIap1) regulates endothelial cell integrity and blood vessel homeostasis - pp1397 - 1402

Massimo M Santoro, Temesgen Samuel, Tracy Mitchell, John C Reed & Didier Y R Stainier

doi:10.1038/ng.2007.8

First paragraph - Birc2 (cIap1) regulates endothelial cell integrity and blood vessel homeostasis | Full Text - Birc2 (cIap1) regulates endothelial cell integrity and blood vessel homeostasis | PDF (506 KB) - Birc2 (cIap1) regulates endothelial cell integrity and blood vessel homeostasis | Supplementary information

See also: News and Views by Mazzone et al.

DAF-16/FOXO targets genes that regulate tumor growth in Caenorhabditis elegans - pp1403 - 1409

Julie Pinkston-Gosse & Cynthia Kenyon

doi:10.1038/ng.2007.1

First paragraph - DAF-16/FOXO targets genes that regulate tumor growth in : Caenorhabditis elegans | Full Text - DAF-16/FOXO targets genes that regulate tumor growth in Caenorhabditis elegans | PDF (385 KB) - DAF-16/FOXO targets genes that regulate tumor growth in Caenorhabditis elegans | Supplementary information

See also: News and Views by Brunet

Light-quality regulation of freezing tolerance in Arabidopsis thaliana - pp1410 - 1413

Keara A Franklin & Garry C Whitelam

doi:10.1038/ng.2007.3

First paragraph - Light-quality regulation of freezing tolerance in : Arabidopsis thaliana | Full Text - Light-quality regulation of freezing tolerance in Arabidopsis thaliana | PDF (328 KB) - Light-quality regulation of freezing tolerance in Arabidopsis thaliana | Supplementary information

See also: News and Views by Kumar & Wigge

Addendum: Germline epimutation of MLH1 in individuals with multiple cancers - p1414

Catherine M Suter, David I K Martin & Robyn L Ward

doi:10.1038/ng1107-1414

Full Text - Addendum: Germline epimutation of MLH1 in individuals with multiple cancers | PDF (130 KB) - Addendum: Germline epimutation of MLH1 in individuals with multiple cancers | Supplementary information