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Letter

Nature Genetics 39, 1397–1402 (1 November 2007) | doi:10.1038/ng.2007.8

Birc2 (cIap1) regulates endothelial cell integrity and blood vessel homeostasis

Massimo M Santoro , Temesgen Samuel , Tracy Mitchell , John C Reed & Didier Y R Stainier

Integrity of the blood vessel wall is essential for vascular homeostasis and organ function. A dynamic balance between endothelial cell survival and apoptosis contributes to this integrity during vascular development and pathological angiogenesis.