News and Views
Nature Genetics 39, 1308 - 1309 (2007)
doi:10.1038/ng1107-1308
Building in resistance to endothelial cell death
Massimiliano Mazzone1, Carmen Ruiz de Almodovar1 & Peter Carmeliet1
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Massimiliano Mazzone, Carmen Ruiz de Almodovar and Peter Carmeliet are at the Center for Transgene Technology and Gene Therapy, Flanders Institute for Biotechnology (VIB), Katholieke Universiteit Leuven (K.U. Leuven), 3000, Leuven, Belgium.
e-mail: peter.carmeliet@med.kuleuven.be
Abstract
A new study in zebrafish shows that Birc2, a member of the inhibitor of apoptosis (IAP) family, is required for endothelial cell survival. This discovery highlights an important in vivo function of this molecule and suggests potential avenues for the development of new antiangiogenic therapies.
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