Brief Communication abstract
Nature Genetics 39, 1197 - 1199 (2007)
Published online: 2 September 2007 | doi:10.1038/ng2108
A QTL influencing F cell production maps to a gene encoding a zinc-finger protein on chromosome 2p15
Stephan Menzel1, Chad Garner2, Ivo Gut3, Fumihiko Matsuda3, Masao Yamaguchi3, Simon Heath3, Mario Foglio3, Diana Zelenika3, Anne Boland3, Helen Rooks1, Steve Best1, Tim D Spector4, Martin Farrall5, Mark Lathrop3 & Swee Lay Thein1,6
F cells measure the presence of fetal hemoglobin, a heritable quantitative trait in adults that accounts for substantial phenotypic diversity of sickle cell disease and 
thalassemia. We applied a genome-wide association mapping strategy to individuals with contrasting extreme trait values and mapped a new F cell quantitative trait locus to BCL11A, which encodes a zinc-finger protein, on chromosome 2p15. The 2p15 BCL11A quantitative trait locus accounts for 15.1% of the trait variance.
- King's College London School of Medicine, Division of Gene and Cell Based Therapy, King's Denmark Hill Campus, London SE5 9PJ, UK.
- University of California at Irvine, Epidemiology Division, Department of Medicine, Irvine, California 92697-7550, USA.
- Centre National de Génotypage, Institut Génomique, Commissariat à l'Energie Atomique, 91006 Evry, France.
- King's College London School of Medicine, Division of Genetics and Molecular Medicine, St. Thomas' Hospital, London SE1 7EH, UK.
- The Wellcome Trust Centre for Human Genetics, Department of Cardiovascular Medicine, University of Oxford, Headington, Oxford OX3 7BN, UK.
- King's College Hospital, Department of Haematological Medicine, Denmark Hill, London SE5 9RS, UK.
Correspondence to: Swee Lay Thein1,6 e-mail: sl.thein@kcl.ac.uk
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