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Letter
Nature Genetics 39, 93–98 (1 January 2007) | doi:10.1038/ng1936
A viable allele of Mcm4 causes chromosome instability and mammary adenocarcinomas in mice
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Abstract
Mcm4 (minichromosome maintenance–deficient 4 homolog) encodes a subunit of the MCM2-7 complex (also known as MCM2–MCM7), the replication licensing factor and presumptive replicative helicase. Here, we report that the mouse chromosome instability mutation Chaos3 (chromosome aberrations occurring spontaneously 3), isolated in a forward genetic screen, is a viable allele of Mcm4.
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