News and Views
Nature Genetics 39, 8 - 9 (2007)
doi:10.1038/ng0107-8
Sending out an SOS
Kevin Shannon1 & Gideon Bollag1
- Kevin Shannon is in the Department of Pediatrics and Comprehensive Cancer Center, University of California at San Francisco, 513 Parnassus Avenue, San Francisco, California 94143, USA.
- Gideon Bollag is at Plexxikon, Inc., 91 Bolivar Drive, Berkeley, California 94710, USA. e-mail: shannonk@peds.ucsf.edu.
Abstract
Noonan syndrome is a disease caused by aberrant signaling through the Ras GTPase, yet the underlying causal mutations remain unknown in many affected individuals. Two papers now identify gain-of-function mutations in the Ras nucleotide exchange factor SOS1 as a new player in this common developmental disorder.
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