News and Views
Nature Genetics 39, 10 - 11 (2007)
doi:10.1038/ng0107-10
Chaotic license for genetic instability and cancer
Anindya Dutta1
- Anindya Dutta is at the Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, Virginia 22908, USA. e-mail: ad8q@virginia.edu
Abstract
Replication initiation factors are essential for cell proliferation and thus are not expected to be disrupted in cancers. Challenging this notion, a new study in mice shows that a hypomorphic mutation in the gene encoding the replication initiation factor Mcm4 leads to genetic instability and predisposes to mammary adenocarcinomas.
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
NEWS AND VIEWS
Research HighlightsNature Structural & Molecular Biology News and Views (01 Nov 2007)
Cell cycle Degradation ensures integrityNature News and Views (19 Jun 2003)
RESEARCH
A viable allele of Mcm4 causes chromosome instability and mammary adenocarcinomas in miceNature Genetics Letter (01 Jan 2007)
A Cdt1?geminin complex licenses chromatin for DNA replication and prevents rereplication during S phase in XenopusThe EMBO Journal Article (13 Dec 2006)
See all 7 matches for Research
