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Letter
Nature Genetics - 38, 1066 - 1070 (2006)
Published online: 30 July 2006; Corrected online: 18 August 2006 | doi:10.1038/ng1857

Reversible model of RNA toxicity and cardiac conduction defects in myotonic dystrophy

Mani S Mahadevan, Ramesh S Yadava, Qing Yu, Sadguna Balijepalli, Carla D Frenzel-McCardell, T David Bourne & Lawrence H Phillips

Supplementary Fig. 1 (pdf 480K)
Transgene expression.

Supplementary Fig. 2 (pdf 204K)
RNA foci in all three muscle lineages in (CTG)200 mice.

Supplementary Fig. 3 (pdf 212K)
CUG-BP1 levels elevated in DM1 muscle.

Supplementary Fig. 4 (pdf 292K)
CUG-BP1 levels increased by toxic RNA.

Supplementary Fig. 5 (pdf 500K)
Comparison of transgene expression in different mouse models of myotonic dystrophy.

Supplementary Fig. 6 (pdf 432K)
Model for the splicing balance created by the mutual antagonism between MBNL1 and CUG-BP1 for splicing events.

Supplementary Methods (pdf 80K)


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Nature Genetics
ISSN: 1061-4036
EISSN: 1546-1718
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