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Letter
Nature Genetics 38, 1049–1054 (1 September 2006) | doi:10.1038/ng1871
CFH haplotypes without the Y402H coding variant show strong association with susceptibility to age-related macular degeneration
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Abstract
In developed countries, age-related macular degeneration is a common cause of blindness in the elderly. A common polymorphism, encoding the sequence variation Y402H in complement factor H (CFH), has been strongly associated with disease susceptibility.
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