Nature Genetics
- 38, 1023 - 1031 (2006)
Published online: 13 August 2006; | doi:10.1038/ng1864
Molecular analysis of flies selected for aggressive behavior
Herman A Dierick & Ralph J Greenspan
The Neurosciences Institute, 10640 John J. Hopkins Drive, San Diego, California 92121, USA.
Correspondence should be addressed to Herman A Dierick dierick@nsi.edu
Aggressive behavior is pervasive throughout the animal kingdom, and yet very little is known about its molecular underpinnings. To address this problem, we have developed a population-based selection procedure to increase aggression in Drosophila melanogaster. We measured changes in aggressive behavior in the selected subpopulations with a new two-male arena assay. In only ten generations of selection, the aggressive lines became markedly more aggressive than the neutral lines. After 21 generations, the fighting index increased more than 30-fold. Using microarray analysis, we identified genes with differing expression levels in the aggressive and neutral lines as candidates for this strong behavioral selection response. We tested a small set of these genes through mutant analysis and found that one significantly increased fighting frequency. These results suggest that selection for increases in aggression can be used to molecularly dissect this behavior.
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