Aurel Betz and James E. Darnell, Jr. are in the Laboratory of Molecular Cell Biology, The Rockefeller University, New York, New York 10021, USA. darnell@rockefeller.edu
Dysregulation of the JAK-STAT pathway is implicated in human cancer and leads to a hematopoietic tumor phenotype in flies. Now, an enhancer-suppressor screen of the fly tumor model connects the JAK kinase Hopscotch pathway with chromatin-modifying proteins and heterochromatic gene silencing.
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