Nature Genetics 38, 866 - 867 (2006)
doi:10.1038/ng0806-866
Nucleic acid by-products and chronic inflammationMarta E Alarcón-Riquelme
Marta E. Alarcón-Riquelme is in the Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Dag Hammarsjölds väg 20, 751 85, Uppsala, Sweden. marta.alarcon@genpat.uu.se
Aicardi-Goutières syndrome (AGS) is an autosomal recessive condition of progressive encephalopathy of early childhood, very similar to congenital viral infections. Two new papers identify four genes mutated in AGS and implicate the processing of DNA and RNA by-products in its pathogenesis.
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