Nature Genetics 38, 862 - 863 (2006)
doi:10.1038/ng0806-862
From worm genetic networks to complex human diseasesHoward Bussey1, Brenda Andrews2 & Charles Boone21
Howard Bussey is in the Biology Department, McGill University, Montreal, Quebec, Canada
2
Brenda Andrews and Charles Boone are in the Banting and Best Department of Medical Research and Department of Medical Genetics and Microbiology, University of Toronto, Toronto, Canada.
charlie.boone@utoronto.ca
Systematic mapping of genetic interactions for Caenorhabditis elegans genes involved in signaling pathways implicated in human disease reveals a network of 350 interactions. The topology of this network resembles that mapped previously in yeast, reinforcing the idea that similar networks may underlie the genetic basis of complex human disease.
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