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Letter

Nature Genetics 38, 663–667 (1 June 2006) | doi:10.1038/ng1816

Evaluating and improving power in whole-genome association studies using fixed marker sets

Itsik Pe'er , Paul I W de Bakker , Julian Maller , Roman Yelensky , David Altshuler & Mark J Daly

Emerging technologies make it possible for the first time to genotype hundreds of thousands of SNPs simultaneously, enabling whole-genome association studies. Using empirical genotype data from the International HapMap Project, we evaluate the extent to which the sets of SNPs contained on three whole-genome genotyping arrays capture common SNPs across the genome, and we find that the majority of common SNPs are well captured by these products either directly or through linkage disequilibrium.