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Letter

Nature Genetics 38, 668–673 (1 June 2006) | doi:10.1038/ng1797

A degradation-sensitive anionic trypsinogen (PRSS2) variant protects against chronic pancreatitis

Heiko Witt , Mikl|[oacute]|s Sahin-T|[oacute]|th , Olfert Landt , Jian-Min Chen , Thilo K|[auml]|hne , Joost PH Drenth , Zolt|[aacute]|n Kukor , Edit Szepessy , Walter Halangk , Stefan Dahm , Klaus Rohde , Hans-Ulrich Schulz , C|[eacute]|dric Le Mar|[eacute]|chal , Nejat Akar , Rudolf W Ammann , Kaspar Truninger , Mario Bargetzi , Eesh Bhatia , Carlo Castellani , Giulia Martina Cavestro , Milos Cerny , Giovanni Destro-Bisol , Gabriella Spedini , Hans Eiberg , Jan B M J Jansen , Monika Koudova , Eva Rausova , Milan Macek , N|[uacute]|ria Malats , Francisco X Real , Hans-J|[uuml]|rgen Menzel , Pedro Moral , Roberta Galavotti , Pier Franco Pignatti , Olga Rickards , Julius Spicak , Narcis Octavian Zarnescu , Wolfgang B|[ouml]|ck , Thomas M Gress , Helmut Friess , Johann Ockenga , Hartmut Schmidt , Roland Pf|[uuml]|tzer , Matthias L|[ouml]|hr , Peter Simon , Frank Ulrich Weiss , Markus M Lerch , Niels Teich , Volker Keim , Thomas Berg , Bertram Wiedenmann , Werner Luck , David Alexander Groneberg , Michael Becker , Thomas Keil , Andreas Kage , Jana Bernardova , Markus Braun , Claudia G|[uuml]|ldner , Juliane Halangk , Jonas Rosendahl , Ulrike Witt , Matthias Treiber , Renate Nickel & Claude F|[eacute]|rec

Chronic pancreatitis is a common inflammatory disease of the pancreas. Mutations in the genes encoding cationic trypsinogen (PRSS1) and the pancreatic secretory trypsin inhibitor (SPINK1) are associated with chronic pancreatitis.