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Letter

Nature Genetics 38, 688–693 (1 June 2006) | doi:10.1038/ng1796

Positional cloning of Sorcs1, a type 2 diabetes quantitative trait locus

Susanne M Clee , Brian S Yandell , Kathryn M Schueler , Mary E Rabaglia , Oliver C Richards , Summer M Raines , Edward A Kabara , Daniel M Klass , Eric T-K Mui , Donald S Stapleton , Mark P Gray-Keller , Matthew B Young , Jonathan P Stoehr , Hong Lan , Igor Boronenkov , Philipp W Raess , Matthew T Flowers & Alan D Attie

We previously mapped the type 2 diabetes mellitus-2 locus (T2dm2), which affects fasting insulin levels, to distal chromosome 19 in a leptin-deficient obese F2 intercross derived from C57BL/6 (B6) and BTBR T+ tf/J (BTBR) mice. Introgression of a 7-Mb segment of the B6 chromosome 19 into the BTBR background (strain 1339A) replicated the reduced insulin linked to T2dm2.