Thomas R. Gingeras is at Affymetrix, Inc., 3380 Central Expressway, Santa Clara, California 95051, USA tom_gingeras@affymetrix.com
The identification of hundreds of thousands of clusters of transcriptional start sites, many located within internal exons of protein-coding genes, indicates that promoter sites are common and that transcriptional organization is complex. This transcriptional architecture implies that most genomic regions serve multiple functions.
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