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Letter
Nature Genetics 38, 589–593 (1 May 2006) | doi:10.1038/ng1774
Ablation of PDK1 in pancreatic |[beta]| cells induces diabetes as a result of loss of |[beta]| cell mass
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Abstract
The total mass of islets of Langerhans is reduced in individuals with type 2 diabetes, possibly contributing to the pathogenesis of this condition. Although the regulation of islet mass is complex, recent studies have suggested the importance of a signaling pathway that includes the insulin or insulin-like growth factor–1 receptors, insulin receptor substrate and phosphatidylinositol (PI) 3-kinase.
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