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Letter
Nature Genetics 38, 479 - 483 (2006)
Published online: 19 March 2006; | doi:10.1038/ng1766

In vivo RNA interference demonstrates a role for Nramp1 in modifying susceptibility to type 1 diabetes

Stephan Kissler, Patrick Stern, Kazue Takahashi, Kara Hunter, Laurence B Peterson & Linda S Wicker

Supplementary Fig. 1 (pdf 344K)
Dose effect of protective alleles at Idd5.2 in the absence of protective alleles at Idd5.1.

Supplementary Fig. 2 (pdf 244K)
Variegated expression in pLL3.7 transgenic mice.

Supplementary Fig. 3 (pdf 304K)
Lentiviral construct expression in pLB-915 founder.

Supplementary Fig. 4 (pdf 348K)
Reduced expression caused by interference between lentiviral constructs.

Supplementary Fig. 5 (pdf 360K)
Nramp1 silencing protects from experimental autoimmune encephalomyelitis (EAE).

Supplementary Table 1 (pdf 12K)
Primer sequences used for cloning and target sequences used for shRNA design.


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Nature Genetics
ISSN: 1061-4036
EISSN: 1546-1718
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