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Brief Communication

Nature Genetics 38, 411–413 (1 April 2006) | doi:10.1038/ng1742

ANG mutations segregate with familial and 'sporadic' amyotrophic lateral sclerosis

Matthew J Greenway , Peter M Andersen , Carsten Russ , Sean Ennis , Susan Cashman , Colette Donaghy , Victor Patterson , Robert Swingler , Dairin Kieran , Jochen Prehn , Karen E Morrison , Andrew Green , K Ravi Acharya , Robert H Brown & Orla Hardiman

We recently identified angiogenin (ANG) as a candidate susceptibility gene for amyotrophic lateral sclerosis (ALS), a neurodegenerative disorder characterized by adult-onset loss of motor neurons. We now report the finding of seven missense mutations in 15 individuals, of whom four had familial ALS and 11 apparently 'sporadic' ALS.