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Letter

Nature Genetics 38, 474–478 (1 April 2006) | doi:10.1038/ng1762

Calcium oxalate urolithiasis in mice lacking anion transporter Slc26a6

Zhirong Jiang , John R Asplin , Andrew P Evan , Vazhaikkurichi M Rajendran , Heino Velazquez , Timothy P Nottoli , Henry J Binder & Peter S Aronson

Urolithiasis is one of the most common urologic diseases in industrialized societies. Calcium oxalate is the predominant component in 70–80% of kidney stones, and small changes in urinary oxalate concentration affect the risk of stone formation.