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Letter

Nature Genetics 38, 463–467 (1 April 2006) | doi:10.1038/ng1754

High mutation rates have driven extensive structural polymorphism among human Y chromosomes

Sjoerd Repping , Saskia K M van Daalen , Laura G Brown , Cindy M Korver , Julian Lange , Janet D Marszalek , Tatyana Pyntikova , Fulco van der Veen , Helen Skaletsky , David C Page & Steve Rozen

Although much structural polymorphism in the human genome has been catalogued, the kinetics of underlying change remain largely unexplored. Because human Y chromosomes are clonally inherited, it has been possible to capture their detailed relationships in a robust, worldwide genealogical tree.