Nature Genetics 38, 418 - 420 (2006)
Published online: 12 March 2006; | doi:10.1038/ng1761
Epistasis and the release of genetic variation during long-term selectionÖrjan Carlborg1, Lina Jacobsson2, Per Åhgren3, Paul Siegel4
& Leif Andersson2, 31
Linnaeus Centre for Bioinformatics, Uppsala University, Box 598, SE-75124 Uppsala, Sweden. 2
Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Box 597, SE-75124 Uppsala, Sweden. 3
Department of Medical Biochemistry and Microbiology, Uppsala University, Box 597, SE-75124 Uppsala, Sweden. 4
Virginia Polytechnic Institute and State University, Department of Animal and Poultry Sciences, Blacksburg, Virginia 24061-0306, USA.
Correspondence should be addressed to Örjan Carlborg orjan.carlborg@lcb.uu.se It is an enigma how long-term selection in model organisms and agricultural species can lead to marked phenotypic changes without exhausting genetic variation for the selected trait. Here, we show that the genetic architecture of an apparently major locus for growth in chicken dissects into a genetic network of four interacting loci. The interactions in this radial network mediate a considerably larger selection response than predicted by a single-locus model.
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