Nature Genetics 38, 400 - 401 (2006)
doi:10.1038/ng0406-400
A sweet link between TGF and vascular disease?Rosemary J Akhurst
Rosemary J. Akhurst is at the Cancer Research Institute, UCSF Comprehensive Cancer Center, University of California, San Francisco, California, USA. rakhurst@cc.ucsf.edu
Mutations in SCL2A10, encoding a glucose transporter, result in arterial tortuosity syndrome, indicating a link between glucose metabolism and angiopathic changes. Intriguingly, some of the phenotypic effects of SCL2A10 ablation may be mediated by upregulation of TGF signaling, suggesting new approaches for therapy of aortic aneurysm.
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