Thomas J. Hudson is in the AllerGen Network and McGill University and Genome Québec Innovation Centre, Montreal, Canada. tom.hudson@mcgill.ca
A new study reports that two common loss-of-function mutations in the gene encoding filaggrin are important risk factors for atopic dermatitis, and interestingly, for asthma in association with atopic dermatitis, but not asthma in the absence of atopic dermatitis. These findings suggest the importance of the epidermal barrier in preventing sensitization to allergens.
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