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Letter

Nature Genetics 38, 320–323 (1 March 2006) | doi:10.1038/ng1732

Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes

Struan F A Grant , Gudmar Thorleifsson , Inga Reynisdottir , Rafn Benediktsson , Andrei Manolescu , Jesus Sainz , Agnar Helgason , Hreinn Stefansson , Valur Emilsson , Anna Helgadottir , Unnur Styrkarsdottir , Kristinn P Magnusson , G Bragi Walters , Ebba Palsdottir , Thorbjorg Jonsdottir , Thorunn Gudmundsdottir , Arnaldur Gylfason , Jona Saemundsdottir , Robert L Wilensky , Muredach P Reilly , Daniel J Rader , Yu Bagger , Claus Christiansen , Vilmundur Gudnason , Gunnar Sigurdsson , Unnur Thorsteinsdottir , Jeffrey R Gulcher , Augustine Kong & Kari Stefansson

We have previously reported suggestive linkage of type 2 diabetes mellitus to chromosome 10q. We genotyped 228 microsatellite markers in Icelandic individuals with type 2 diabetes and controls throughout a 10.5-Mb interval on 10q.