Nature Genetics 38, 274 - 276 (2006)
doi:10.1038/ng0306-274
Genetics and epigenetics of hydatidiform molesTimothy H Bestor1
& Déborah Bourc'his21
Timothy H. Bestor is in the Department of Genetics and Development College of Physicians and Surgeons, Columbia University, 701 West 168th Street, New York, New York 10032, USA. THB12@columbia.edu
2
Déborah Bourc'his is at Institut National de la Santé et de la Recherche Médicale, U741, Paris 7 University, 2 Place Jussieu, 75251 Paris Cedex 05, France. Human embryos that develop in the presence of chromosomes solely of paternal origin give rise only to a disorganized mass of placental derivatives known as a complete hydatidiform mole. A new study reports that mutations in NALP7, a gene thought to be involved in inflammatory and apoptotic pathways, occur in human females whose biparental conceptuses can develop as apparent complete moles.
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