Evidence for an instructive mechanism of de novo methylation in cancer cellspp149 - 153 Ilana Keshet, Yeshayahu Schlesinger, Shlomit Farkash, Eyal Rand, Merav Hecht, Eran Segal, Eli Pikarski, Richard A Young, Alain Niveleau, Howard Cedar
& Itamar Simon Published online: 24 January 2006|doi:10.1038/ng1719 Abstract|Full text|PDF
(403K)
|Supplementary Information
MKS1, encoding a component of the flagellar apparatus basal body proteome, is mutated in Meckel syndromepp155 - 157 Mira Kyttälä, Jonna Tallila, Riitta Salonen, Outi Kopra, Nicolai Kohlschmidt, Paulina Paavola-Sakki, Leena Peltonen
& Marjo Kestilä Published online: 15 January 2006|doi:10.1038/ng1714 Abstract|Full text|PDF
(224K)
|Supplementary Information See also:News and Views by Katsanis|Letter by Smith et al.
Comparative analysis of chimpanzee and human Y chromosomes unveils complex evolutionary pathwaypp158 - 167 Yoko Kuroki, Atsushi Toyoda, Hideki Noguchi, Todd D Taylor, Takehiko Itoh, Dae-Soo Kim, Dae-Won Kim, Sang-Haeng Choi, Il-Chul Kim, Han Ho Choi, Yong Sung Kim, Yoko Satta, Naruya Saitou, Tomoyuki Yamada, Shinichi Morishita, Masahira Hattori, Yoshiyuki Sakaki, Hong-Seog Park
& Asao Fujiyama Published online: 01 January 2006|doi:10.1038/ng1729 Abstract|Full text|PDF
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|Supplementary Information See also:News and Views by Tyler-Smith et al.
Evolution of new protein topologies through multistep gene rearrangementspp168 - 174 Sergio G Peisajovich, Liat Rockah
& Dan S Tawfik Published online: 15 January 2006|doi:10.1038/ng1717 Abstract|Full text|PDF
(374K)
|Supplementary Information
Cooperative and antagonistic interactions between Sall4 and Tbx5 pattern the mouse limb and heartpp175 - 183 Kazuko Koshiba-Takeuchi, Jun K Takeuchi, Eric P Arruda, Irfan S Kathiriya, Rong Mo, Chi-chung Hui, Deepak Srivastava
& Benoit G Bruneau Published online: 25 December 2005|doi:10.1038/ng1707 Abstract|Full text|PDF
(889K)
|Supplementary Information
Spectrin mutations cause spinocerebellar ataxia type 5pp184 - 190 Yoshio Ikeda, Katherine A Dick, Marcy R Weatherspoon, Dan Gincel, Karen R Armbrust, Joline C Dalton, Giovanni Stevanin, Alexandra Dürr, Christine Zühlke, Katrin Bürk, H Brent Clark, Alexis Brice, Jeffrey D Rothstein, Lawrence J Schut, John W Day
& Laura P W Ranum Published online: 22 January 2006|doi:10.1038/ng1728 Abstract|Full text|PDF
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|Supplementary Information
The transmembrane protein meckelin (MKS3) is mutated in Meckel-Gruber syndrome and the wpk ratpp191 - 196 Ursula M Smith, Mark Consugar, Louise J Tee, Brandy M McKee, Esther N Maina, Shelly Whelan, Neil V Morgan, Erin Goranson, Paul Gissen, Stacie Lilliquist, Irene A Aligianis, Christopher J Ward, Shanaz Pasha, Rachaneekorn Punyashthiti, Saghira Malik Sharif, Philip A Batman, Christopher P Bennett, C Geoffrey Woods, Carole McKeown, Martine Bucourt, Caroline A Miller, Phillip Cox, Lihadh AlGazali, Richard C Trembath, Vicente E Torres, Tania Attie-Bitach, Deirdre A Kelly, Eamonn R Maher, Vincent H Gattone II, Peter C Harris
& Colin A Johnson Published online: 15 January 2006|doi:10.1038/ng1713 Abstract|Full text|PDF
(458K)
|Supplementary Information See also:News and Views by Katsanis|Brief Communication by Kyttälä et al.
Disrupted function and axonal distribution of mutant tyrosyl-tRNA synthetase in dominant intermediate Charcot-Marie-Tooth neuropathypp197 - 202 Albena Jordanova, Joy Irobi, Florian P Thomas, Patrick Van Dijck, Kris Meerschaert, Maarten Dewil, Ines Dierick, An Jacobs, Els De Vriendt, Velina Guergueltcheva, Chitharanjan V Rao, Ivailo Tournev, Francisco A A Gondim, Marc D'Hooghe, Veerle Van Gerwen, Patrick Callaerts, Ludo Van Den Bosch, Jean-Pièrre Timmermans, Wim Robberecht, Jan Gettemans, Johan M Thevelein, Peter De Jonghe, Ivo Kremensky
& Vincent Timmerman Published online: 22 January 2006|doi:10.1038/ng1727 Abstract|Full text|PDF
(478K)
|Supplementary Information
A unified mixed-model method for association mapping that accounts for multiple levels of relatednesspp203 - 208 Jianming Yu, Gael Pressoir, William H Briggs, Irie Vroh Bi, Masanori Yamasaki, John F Doebley, Michael D McMullen, Brandon S Gaut, Dahlia M Nielsen, James B Holland, Stephen Kresovich
& Edward S Buckler Published online: 25 December 2005|doi:10.1038/ng1702 Abstract|Full text|PDF
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|Supplementary Information
Joint analysis is more efficient than replication-based analysis for two-stage genome-wide association studiespp209 - 213 Andrew D Skol, Laura J Scott, Gonçalo R Abecasis
& Michael Boehnke Published online: 15 January 2006|doi:10.1038/ng1706 Abstract|Full text|PDF
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Evaluating potential for whole-genome studies in Kosrae, an isolated population in Micronesiapp214 - 217 Penelope E Bonnen, Itsik Pe'er, Robert M Plenge, Jackie Salit, Jennifer K Lowe, Michael H Shapero, Richard P Lifton, Jan L Breslow, Mark J Daly, David E Reich, Keith W Jones, Markus Stoffel, David Altshuler
& Jeffrey M Friedman Published online: 22 January 2006|doi:10.1038/ng1712 Abstract|Full text|PDF
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The sex-specific genetic architecture of quantitative traits in humanspp218 - 222 Lauren A Weiss, Lin Pan, Mark Abney
& Carole Ober Published online: 22 January 2006|doi:10.1038/ng1726 Abstract|Full text|PDF
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Conserved noncoding sequences are selectively constrained and not mutation cold spotspp223 - 227 Jared A Drake, Christine Bird, James Nemesh, Daryl J Thomas, Christopher Newton-Cheh, Alexandre Reymond, Laurent Excoffier, Homa Attar, Stylianos E Antonarakis, Emmanouil T Dermitzakis
& Joel N Hirschhorn Published online: 25 December 2005|doi:10.1038/ng1710 Abstract|Full text|PDF
(174K)
|Supplementary Information
The role of microRNA-1 and microRNA-133 in skeletal muscle proliferation and differentiationpp228 - 233 Jian-Fu Chen, Elizabeth M Mandel, J Michael Thomson, Qiulian Wu, Thomas E Callis, Scott M Hammond, Frank L Conlon
& Da-Zhi Wang Published online: 25 December 2005|doi:10.1038/ng1725 Abstract|Full text|PDF
(375K)
|Supplementary Information
Physiogenomic resources for rat models of heart, lung and blood disorderspp234 - 239 Renae L Malek, Hong-ying Wang, Anne E Kwitek, Andrew S Greene, Nirmal Bhagabati, Gretta Borchardt, Lisa Cahill, Tracey Currier, Bryan Frank, Xianping Fu, Michael Hasinoff, Eleanor Howe, Noah Letwin, Truong V Luu, Alexander Saeed, Hedieh Sajadi, Steven L Salzberg, Razvan Sultana, Mathangi Thiagarajan, Jennifer Tsai, Kathleen Veratti, Joseph White, John Quackenbush, Howard J Jacob
& Norman H Lee Published online: 15 January 2006|doi:10.1038/ng1693 Abstract|Full text|PDF
(358K)
|Supplementary Information See also:News and Views by Hubner
Trak1 mutation disrupts GABAA receptor homeostasis in hypertonic micepp245 - 250 Sandra L Gilbert, Li Zhang, Michele L Forster, Tamaki Iwase, Betty Soliven, Leah Rae Donahue, Hope O Sweet, Roderick T Bronson, Muriel T Davisson, Robert L Wollmann
& Bruce T Lahn Published online: 25 December 2005|doi:10.1038/ng1715 Abstract|Full text|PDF
(426K)
|Supplementary Information
Identification of direct DAF-16 targets controlling longevity, metabolism and diapause by chromatin immunoprecipitationpp251 - 257 Seung Wook Oh, Arnab Mukhopadhyay, Bharat L Dixit, Tamal Raha, Michael R Green
& Heidi A Tissenbaum Published online: 25 December 2005|doi:10.1038/ng1723 Abstract|Full text|PDF
(245K)
|Supplementary Information
Induction, suppression and requirement of RNA silencing pathways in virulent Agrobacterium tumefaciens infectionspp258 - 263 Patrice Dunoyer, Christophe Himber
& Olivier Voinnet Published online: 22 January 2006|doi:10.1038/ng1722 Abstract|Full text|PDF
(416K)
|Supplementary Information See also:News and Views by Waterhouse
Corrigendum: Deficiency of UBR1, a ubiquitin ligase of the N-end rule pathway, causes pancreatic dysfunction, malformations and mental retardation (Johanson-Blizzard syndrome)p265 Martin Zenker, Julia Mayerle, Markus M Lerch, Andreas Tagariello, Klaus Zerres, Peter R Durie, Matthias Beier, Georg Hülskamp, Celina Guzman, Helga Rehder, Frits A Beemer, Ben Hamel, Philippe Vanlieferinghen, Ruth Gershoni-Baruch, Marta W Vieira, Miroslav Dumic, Ron Auslender, Vera L Gil-da-Silva-Lopes, Simone Steinlicht, Manfred Rauh, Stavit A Shalev, Christian Thiel, Arif B Ekici, Andreas Winterpacht, Yong Tae Kwon, Alexander Varshavsky
& André Reis doi:10.1038/ng0206-265 Full text|PDF
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