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Letter

Nature Genetics 38, 218–222 (1 February 2006) | doi:10.1038/ng1726

The sex-specific genetic architecture of quantitative traits in humans

Lauren A Weiss , Lin Pan , Mark Abney & Carole Ober

Mapping genetically complex traits remains one of the greatest challenges in human genetics today. In particular, gene-environment and gene-gene interactions, genetic heterogeneity and incomplete penetrance make thorough genetic dissection of complex traits difficult, if not impossible.