Access

Letter

Nature Genetics 38, 228–233 (1 February 2006) | doi:10.1038/ng1725

The role of microRNA-1 and microRNA-133 in skeletal muscle proliferation and differentiation

Jian-Fu Chen , Elizabeth M Mandel , J Michael Thomson , Qiulian Wu , Thomas E Callis , Scott M Hammond , Frank L Conlon & Da-Zhi Wang

Understanding the molecular mechanisms that regulate cellular proliferation and differentiation is a central theme of developmental biology. MicroRNAs (miRNAs) are a class of regulatory RNAs of |[sim]|22 nucleotides that post-transcriptionally regulate gene expression.