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Letter
Nature Genetics 38, 240–244 (1 February 2006) | doi:10.1038/ng1724
Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin
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Abstract
The pathogenesis of Bacillus anthracis, the bacterium that causes anthrax, depends on secretion of three factors that combine to form two bipartite toxins. Edema toxin, consisting of protective antigen (PA) and edema factor (EF), causes the edema associated with cutaneous anthrax infections, whereas lethal toxin (LeTx), consisting of PA and lethal factor (LF), is believed to be responsible for causing death in systemic anthrax infections.
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