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Letter

Nature Genetics 38, 251–257 (1 February 2006) | doi:10.1038/ng1723

Identification of direct DAF-16 targets controlling longevity, metabolism and diapause by chromatin immunoprecipitation

Seung Wook Oh , Arnab Mukhopadhyay , Bharat L Dixit , Tamal Raha , Michael R Green & Heidi A Tissenbaum

DAF-16, a forkhead transcription factor, is a key regulator of longevity, metabolism and dauer diapause in Caenorhabditis elegans. The precise mechanism by which DAF-16 regulates multiple functions, however, is poorly understood.