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Letter

Nature Genetics 38, 245–250 (1 February 2006) | doi:10.1038/ng1715

Trak1 mutation disrupts GABAA receptor homeostasis in hypertonic mice

Sandra L Gilbert , Li Zhang , Michele L Forster , Tamaki Iwase , Betty Soliven , Leah Rae Donahue , Hope O Sweet , Roderick T Bronson , Muriel T Davisson , Robert L Wollmann & Bruce T Lahn

Hypertonia, which results from motor pathway defects in the central nervous system (CNS), is observed in numerous neurological conditions, including cerebral palsy, stroke, spinal cord injury, stiff-person syndrome, spastic paraplegia, dystonia and Parkinson disease. Mice with mutation in the hypertonic (hyrt) gene exhibit severe hypertonia as their primary symptom.