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Letter

Nature Genetics 38, 203–208 (1 February 2006) | doi:10.1038/ng1702

A unified mixed-model method for association mapping that accounts for multiple levels of relatedness

Jianming Yu , Gael Pressoir , William H Briggs , Irie Vroh Bi , Masanori Yamasaki , John F Doebley , Michael D McMullen , Brandon S Gaut , Dahlia M Nielsen , James B Holland , Stephen Kresovich & Edward S Buckler

As population structure can result in spurious associations, it has constrained the use of association studies in human and plant genetics. Association mapping, however, holds great promise if true signals of functional association can be separated from the vast number of false signals generated by population structure.