Access

Letter

Nature Genetics 38, 1419–1423 (1 December 2006) | doi:10.1038/ng1920

Conservation of hotspots for recombination in low-copy repeats associated with the NF1 microdeletion

Thomas De Raedt , Matthew Stephens , Ine Heyns , Hilde Brems , Daisy Thijs , Ludwine Messiaen , Karen Stephens , Conxi Lazaro , Katharina Wimmer , Hildegard Kehrer-Sawatzki , Dominique Vidaud , Lan Kluwe , Peter Marynen & Eric Legius

Several large-scale studies of human genetic variation have provided insights into processes such as recombination that have shaped human diversity. However, regions such as low-copy repeats (LCRs) have proven difficult to characterize, hindering efforts to understand the processes operating in these regions.