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Letter

Nature Genetics 38, 1430–1434 (1 December 2006) | doi:10.1038/ng1919

In germ cells of mouse embryonic ovaries, the decision to enter meiosis precedes premeiotic DNA replication

Andrew E Baltus , Douglas B Menke , Yueh-Chiang Hu , Mary L Goodheart , Anne E Carpenter , Dirk G de Rooij & David C Page

The transition from mitosis to meiosis is a defining juncture in the life cycle of sexually reproducing organisms. In yeast, the decision to enter meiosis is made before the single round of DNA replication that precedes the two meiotic divisions.