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Letter

Nature Genetics 38, 1446–1451 (1 December 2006) | doi:10.1038/ng1917

A chromatin-mediated mechanism for specification of conditional transcription factor targets

Michael J Buck & Jason D Lieb

Organisms respond to changes in their environment, and many such responses are initiated at the level of gene transcription. Here, we provide evidence for a previously undiscovered mechanism for directing transcriptional regulators to new binding targets in response to an environmental change.