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Letter

Nature Genetics 38, 1440–1445 (1 December 2006) | doi:10.1038/ng1915

Genomic and functional evolution of the Drosophila melanogaster sperm proteome

Steve Dorus , Scott A Busby , Ursula Gerike , Jeffrey Shabanowitz , Donald F Hunt & Timothy L Karr

In addition to delivering a haploid genome to the egg, sperm have additional critical functions, including egg activation, origination of the zygote centrosome and delivery of paternal factors. Despite this, existing knowledge of the molecular basis of sperm form and function is limited.