Nature Genetics
- 38, 1359 - 1360 (2006)
doi:10.1038/ng1206-1359
Toward a human epigenomeRomulo M Brena, Tim H-M Huang & Christoph Plass
Romulo M. Brena is in the Division of Human Cancer Genetics, Department of Molecular Genetics and Department of Molecular Virology, Immunology and Medical Genetics, and Tim H.-M. Huang and Christoph Plass are in the Division of Human Cancer Genetics, Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Columbus, Ohio 43210, USA. Christoph.Plass@osumc.edu
Sequencing of genomes, including that of humans, has revolutionized our understanding of genome organization and accelerated the hunt for disease-causing mutations. New studies by the Human Epigenome Project (HEP) now highlight the importance and complexity of cytosine DNA methylation in tissue-specific regulation of gene expression.
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