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Letter

Nature Genetics 38, 1341–1347 (1 November 2006) | doi:10.1038/ng1891

Circular chromosome conformation capture (4C) uncovers extensive networks of epigenetically regulated intra- and interchromosomal interactions

Zhihu Zhao , Gholamreza Tavoosidana , Mikael Sj|[ouml]|linder , Anita G|[ouml]|nd|[ouml]|r , Piero Mariano , Sha Wang , Chandrasekhar Kanduri , Magda Lezcano , Kuljeet Singh Sandhu , Umashankar Singh , Vinod Pant , Vijay Tiwari , Sreenivasulu Kurukuti & Rolf Ohlsson

Accumulating evidence converges on the possibility that chromosomes interact with each other to regulate transcription in trans. To systematically explore the epigenetic dimension of such interactions, we devised a strategy termed circular chromosome conformation capture (4C).