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Volume 38 Issue 11, November 2006

Cover art: "Branch" by Bryan Nash Gill bgill0536@charter.net. Photography by Allen Phillips allen.phillips@wadsworthatheneum.org.

Volume 38 Issue 11

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Editorial

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Correspondence

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News & Views

  • The recently completed International HapMap Project has provided detailed information about patterns of genetic variation in four different population samples. Two new studies show that the patterns of variation documented in the HapMap can be applied to other human populations, suggesting it is time to establish a standardized platform for all whole-genome association studies.

    • Anna C Need
    • David B Goldstein
    News & Views

  • A new study shows that during transcription, the TH2 interleukin gene cluster is organized into several small chromatin loops connected at their base by the protein SATB1. This first detailed glimpse of chromatin folding provides a new perspective on the coordination of cell type–specific gene expression.

    • Anita Göndör
    • Rolf Ohlsson
    News & Views

  • Two new reports extend the functions of DMP1, a bone matrix protein involved in mineralization, to phosphate regulation. These discoveries provide insight into the mechanism by which bone may coordinate systemic phosphate balance with the needs of mineralizing bone.

    • Susan C Schiavi
    News & Views

  • Reactive oxygen species (ROS) are traditionally viewed as the toxic by-product of cellular respiration. A new study suggests a homeostatic role for ROS in maintaining stable respiratory phenotypes across genetic variants of the mitochondrial genome.

    • Joshua M Baughman
    • Vamsi K Mootha
    News & Views

  • Female-to-male sex reversal is an extremely rare and puzzling phenomenon. A new study identifies mutations in the gene encoding R-spondin1 in XX sex-reversed individuals and suggests that antagonistic pathways in the bipotential gonad regulate sex determination.

    • Blanche Capel
    News & Views
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