Comparison of a proteomic approach with a microarray-based approach to detect exons in the mouse genomepp1223 - 1224 Quan-Hu Sheng, Lian-Shui Wang, Jie Dai, Xiao-Sheng Jiang, Rong Xia Li, Dan-Jun Ma, Yi-Xue Li, Rong Zeng & Jia-Rui Wu doi:10.1038/ng1106-1223 Full text|PDF
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Contribution of consanguinuity to polygenic and multifactorial diseasespp1224 - 1225 Igor Rudan, Harry Campbell, Andrew D Carothers, Nicholas D Hastie & Alan F Wright doi:10.1038/ng1106-1224 Full text|PDF
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Truncating mutations in the Fanconi anemia J gene BRIP1 are low-penetrance breast cancer susceptibility allelespp1239 - 1241 Sheila Seal, Deborah Thompson, Anthony Renwick, Anna Elliott, Patrick Kelly, Rita Barfoot, Tasnim Chagtai, Hiran Jayatilake, Munaza Ahmed, Katarina Spanova, Bernard North, Lesley McGuffog, D Gareth Evans, Diana Eccles, The Breast Cancer Susceptibility
Collaboration (UK), Douglas F Easton, Michael R Stratton & Nazneen Rahman Published online: 08 October 2006|doi:10.1038/ng1902 Abstract|Full text|PDF
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Mutations in FRMD7, a newly identified member of the FERM family, cause X-linked idiopathic congenital nystagmuspp1242 - 1244 Patrick Tarpey, Shery Thomas, Nagini Sarvananthan, Uma Mallya, Steven Lisgo, Chris J Talbot, Eryl O Roberts, Musarat Awan, Mylvaganam Surendran, Rebecca J McLean, Robert D Reinecke, Andrea Langmann, Susanne Lindner, Martina Koch, Sunila Jain, Geoffrey Woodruff, Richard P Gale, Chris Degg, Konstantinos Droutsas, Ioannis Asproudis, Alina A Zubcov, Christina Pieh, Colin D Veal, Rajiv D Machado, Oliver C Backhouse, Laura Baumber, Cris S Constantinescu, Michael C Brodsky, David G Hunter, Richard W Hertle, Randy J Read, Sarah Edkins, Sarah O'Meara, Adrian Parker, Claire Stevens, Jon Teague, Richard Wooster, P Andrew Futreal, Richard C Trembath, Michael R Stratton, F Lucy Raymond & Irene Gottlob Published online: 01 October 2006|doi:10.1038/ng1893 Abstract|Full text|PDF
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The gene encoding R-spondin 4 (RSPO4), a secreted protein implicated in Wnt signaling, is mutated in inherited anonychiapp1245 - 1247 Diana C Blaydon, Yoshiyuki Ishii, Edel A O'Toole, Harriet C Unsworth, Muy-Teck Teh, Franz Rüschendorf, Claire Sinclair, Väinö K Hopsu-Havu, Nicholas Tidman, Celia Moss, Rosemarie Watson, David de Berker, Muhammad Wajid, Angela M Christiano & David P Kelsell Published online: 15 October 2006|doi:10.1038/ng1883 Abstract|Full text|PDF
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DMP1 mutations in autosomal recessive hypophosphatemia implicate a bone matrix protein in the regulation of phosphate homeostasispp1248 - 1250 Bettina Lorenz-Depiereux, Murat Bastepe, Anna Benet-Pagès, Mustapha Amyere, Janine Wagenstaller, Ursula Müller-Barth, Klaus Badenhoop, Stephanie M Kaiser, Roger S Rittmaster, Alan H Shlossberg, José L Olivares, César Loris, Feliciano J Ramos, Francis Glorieux, Miikka Vikkula, Harald Jüppner & Tim M Strom Published online: 08 October 2006|doi:10.1038/ng1868 Abstract|Full text|PDF
(138K)
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A worldwide survey of haplotype variation and linkage disequilibrium in the human genomepp1251 - 1260 Donald F Conrad, Mattias Jakobsson, Graham Coop, Xiaoquan Wen, Jeffrey D Wall, Noah A Rosenberg & Jonathan K Pritchard Published online: 22 October 2006|doi:10.1038/ng1911 Abstract|Full text|PDF
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Differences in reactive oxygen species production explain the phenotypes associated with common mouse mitochondrial DNA variantspp1261 - 1268 Raquel Moreno-Loshuertos, Rebeca Acín-Pérez, Patricio Fernández-Silva, Nieves Movilla, Acisclo Pérez-Martos, Santiago Rodriguez de Cordoba, M Esther Gallardo & José Antonio Enríquez Published online: 01 October 2006|doi:10.1038/ng1897 Abstract|Full text|PDF
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Essential role of Jun family transcription factors in PU.1 knockdown–induced leukemic stem cellspp1269 - 1277 Ulrich Steidl, Frank Rosenbauer, Roel G W Verhaak, Xuesong Gu, Alexander Ebralidze, Hasan H Otu, Steffen Klippel, Christian Steidl, Ingmar Bruns, Daniel B Costa, Katharina Wagner, Manuel Aivado, Guido Kobbe, Peter J M Valk, Emmanuelle Passegué, Towia A Libermann, Ruud Delwel & Daniel G Tenen Published online: 15 October 2006|doi:10.1038/ng1898 Abstract|Full text|PDF
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Genome-wide analysis of estrogen receptor binding sitespp1289 - 1297 Jason S Carroll, Clifford A Meyer, Jun Song, Wei Li, Timothy R Geistlinger, Jérôme Eeckhoute, Alexander S Brodsky, Erika Krasnickas Keeton, Kirsten C Fertuck, Giles F Hall, Qianben Wang, Stefan Bekiranov, Victor Sementchenko, Edward A Fox, Pamela A Silver, Thomas R Gingeras, X Shirley Liu & Myles Brown Published online: 01 October 2006|doi:10.1038/ng1901 Abstract|Full text|PDF
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Transferability of tag SNPs in genetic association studies in multiple populationspp1298 - 1303 Paul I W de Bakker, Noël P Burtt, Robert R Graham, Candace Guiducci, Roman Yelensky, Jared A Drake, Todd Bersaglieri, Kathryn L Penney, Johannah Butler, Stanton Young, Robert C Onofrio, Helen N Lyon, Daniel O Stram, Christopher A Haiman, Matthew L Freedman, Xiaofeng Zhu, Richard Cooper, Leif Groop, Laurence N Kolonel, Brian E Henderson, Mark J Daly, Joel N Hirschhorn & David Altshuler Published online: 22 October 2006|doi:10.1038/ng1899 Abstract|Full text|PDF
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R-spondin1 is essential in sex determination, skin differentiation and malignancypp1304 - 1309 Pietro Parma, Orietta Radi, Valerie Vidal, Marie Christine Chaboissier, Elena Dellambra, Stella Valentini, Liliana Guerra, Andreas Schedl & Giovanna Camerino Published online: 15 October 2006|doi:10.1038/ng1907 Abstract|Full text|PDF
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Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolismpp1310 - 1315 Jian Q Feng, Leanne M Ward, Shiguang Liu, Yongbo Lu, Yixia Xie, Baozhi Yuan, Xijie Yu, Frank Rauch, Siobhan I Davis, Shubin Zhang, Hector Rios, Marc K Drezner, L Darryl Quarles, Lynda F Bonewald & Kenneth E White Published online: 08 October 2006|doi:10.1038/ng1905 Abstract|Full text|PDF
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Regulation of primary cilia formation and left-right patterning in zebrafish by a noncanonical Wnt signaling mediator, duborayapp1316 - 1322 Isao Oishi, Yasuhiko Kawakami, Ángel Raya, Carles Callol-Massot & Juan Carlos Izpisúa Belmonte Published online: 01 October 2006|doi:10.1038/ng1892 Abstract|Full text|PDF
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Differentiated cells are more efficient than adult stem cells for cloning by somatic cell nuclear transferpp1323 - 1328 Li-Ying Sung, Shaorong Gao, Hongmei Shen, Hui Yu, Yifang Song, Sadie L Smith, Ching-Chien Chang, Kimiko Inoue, Lynn Kuo, Jin Lian, Ao Li, X Cindy Tian, David P Tuck, Sherman M Weissman, Xiangzhong Yang & Tao Cheng Published online: 01 October 2006|doi:10.1038/ng1895 Abstract|Full text|PDF
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Irf6 is a key determinant of the keratinocyte proliferation-differentiation switchpp1329 - 1334 Rebecca J Richardson, Jill Dixon, Saimon Malhotra, Matthew J Hardman, Lynnette Knowles, Ray P Boot-Handford, Paul Shore, Alan Whitmarsh & Michael J Dixon Published online: 15 October 2006|doi:10.1038/ng1894 Abstract|Full text|PDF
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Abnormal skin, limb and craniofacial morphogenesis in mice deficient for interferon regulatory factor 6 (Irf6)pp1335 - 1340 Christopher R Ingraham, Akira Kinoshita, Shinji Kondo, Baoli Yang, Samin Sajan, Kurt J Trout, Margaret I Malik, Martine Dunnwald, Stephen L Goudy, Michael Lovett, Jeffrey C Murray & Brian C Schutte Published online: 15 October 2006|doi:10.1038/ng1903 Abstract|Full text|PDF
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Circular chromosome conformation capture (4C) uncovers extensive networks of epigenetically regulated intra- and interchromosomal interactionspp1341 - 1347 Zhihu Zhao, Gholamreza Tavoosidana, Mikael Sjölinder, Anita Göndör, Piero Mariano, Sha Wang, Chandrasekhar Kanduri, Magda Lezcano, Kuljeet Singh Sandhu, Umashankar Singh, Vinod Pant, Vijay Tiwari, Sreenivasulu Kurukuti & Rolf Ohlsson Published online: 08 October 2006|doi:10.1038/ng1891 Abstract|Full text|PDF
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Nuclear organization of active and inactive chromatin domains uncovered by chromosome conformation capture–on-chip (4C)pp1348 - 1354 Marieke Simonis, Petra Klous, Erik Splinter, Yuri Moshkin, Rob Willemsen, Elzo de Wit, Bas van Steensel & Wouter de Laat Published online: 08 October 2006|doi:10.1038/ng1896 Abstract|Full text|PDF
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