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Letter

Nature Genetics 38, 1298–1303 (1 November 2006) | doi:10.1038/ng1899

Transferability of tag SNPs in genetic association studies in multiple populations

Paul I W de Bakker , No|[euml]|l P Burtt , Robert R Graham , Candace Guiducci , Roman Yelensky , Jared A Drake , Todd Bersaglieri , Kathryn L Penney , Johannah Butler , Stanton Young , Robert C Onofrio , Helen N Lyon , Daniel O Stram , Christopher A Haiman , Matthew L Freedman , Xiaofeng Zhu , Richard Cooper , Leif Groop , Laurence N Kolonel , Brian E Henderson , Mark J Daly , Joel N Hirschhorn & David Altshuler

A general question for linkage disequilibrium–based association studies is how power to detect an association is compromised when tag SNPs are chosen from data in one population sample and then deployed in another sample. Specifically, it is important to know how well tags picked from the HapMap DNA samples capture the variation in other samples.