Nature Genetics
- 38, 1105 - 1106 (2006)
doi:10.1038/ng1006-1105
A WNK in the kidney controls blood pressureThomas M Coffman
Thomas M. Coffman is in the Division of Nephrology, Department of Medicine, Duke University and the Durham Veterans Administration Medical Centers, Durham, North Carolina, 27710 USA. tcoffman@duke.edu
Precise control of sodium excretion by the kidney is critical for maintaining fluid and electrolyte homeostasis. A new mouse model provides compelling evidence that a kinase, WNK4, provides key signals for regulating blood pressure and potassium balance by controlling the structure and function of the distal convoluted tubule.
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