Nature Genetics
- 38, 1104 - 1105 (2006)
doi:10.1038/ng1006-1104
New evidence that DNA encodes its packagingSevinc Ercan & Jason D. Lieb
Sevinc Ercan and Jason D. Lieb are in the Department of Biology and Carolina Center for the Genome Sciences, 202 Fordham Hall, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-3280, USA. jlieb@bio.unc.edu
New experimental approaches combined with statistical models show that DNA sequence strongly influences how the genome is packaged into nucleosomes. The studies predict that genes regulated by fundamentally different mechanisms have distinct nucleosome positioning signatures encoded in their DNA.
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