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Brief Communication
Nature Genetics 38, 21–23 (1 January 2006) | doi:10.1038/ng1701
Defective planar cell polarity in polycystic kidney disease
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Abstract
Morphogenesis involves coordinated proliferation, differentiation and spatial distribution of cells. We show that lengthening of renal tubules is associated with mitotic orientation of cells along the tubule axis, demonstrating intrinsic planar cell polarization, and we demonstrate that mitotic orientations are significantly distorted in rodent polycystic kidney models.
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